国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 276-279.doi: 10.3760/cma.j.issn.1673422X.2014.04.012

• 综述 • 上一篇    下一篇

K-ras基因在非小细胞肺癌中的作用

王柳春, 李凯   

  1. 300060 天津医科大学肿瘤医院肺部肿瘤内科 国家肿瘤临床医学研究中心
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 王柳春，Email: wliuch@126.com E-mail:wliuch@126.com

Roles of Kras gene in nonsmall cell lung cancer

WANG  Liu-Chun, LI  Kai   

  1. Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer, Tianjin 300060, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Wang Liuchun E-mail:wliuch@126.com

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摘要： K-ras基因是非小细胞肺癌的原癌基因之一，其突变后可通过多种信号途径促进肿瘤细胞生长，且在吸烟的肺腺癌人群中突变率较高。目前研究认为Kras基因突变对靶向治疗原发耐药，且可能成为一个预后不良的标志物。

关键词: 癌, 非小细胞肺, 预后, 抗药性, 肿瘤, K-ras基因

Abstract: K-ras gene is one of oncogenes in nonsmall cell lung cancer, and it can promote tumor cells growth after mutations by several signaling pathways. Kras mutations frequently occur in lung adenocarcinoma patients with smoking history. In the present study, Kras mutations are associated with resistence to targated therapy and may be a marker of poor prognosis in patients with nonsmall cell lung cancer.

Key words: Carcinoma, nonsmallcell lung, Prognosis, Drug resistance, neoplasm, Kras gene