双向负反馈环路lin28-let-7与肿瘤

doi:10.3760/cma.j.issn.1673-422X.2014.03.002

摘要/Abstract

摘要： let-7家族是重要的肿瘤抑制因子，在干细胞分化和肿瘤抑制中起重要作用。RNA结合蛋白lin28是重要的干细胞因子，能维持细胞干性，促进细胞恶性转化。lin28可与let-7前体结合，阻断let-7成熟；而let-7可结合至lin28 mRNA的3′非翻译区（UTR），抑制lin28表达。lin28-let-7形成一个双向负反馈环路，参与干细胞分化、肿瘤发生、侵袭转移、耐药复发等生物过程，可作为肿瘤治疗新靶点。

关键词: 肿瘤, 微RNAs, RNA结合蛋白质类, 肿瘤干细胞

Abstract: The microRNA let-7 family, functioning as a tumor suppressor, has emerged as a regulator of stem cell differentiation and tumor repression. The RNA-binding protein lin28 is a stem cell pluripotency factor, which contributes to the maintenance of stem cell characteristics and promoting cell malignant transformation. lin28 can block the maturity of let-7 by combining with the precursors of let-7 family miRNAs, which is itself able to repress lin28 by binding to the 3′-UTR of lin28 transcripts, thus forming a feedback loop. The doublenegative feedback loop comprising lin28 and let-7 is involved in several biological processes such as differentiation of stem cell, tumorigenesis, invasion and metastasis, drug resistance and relapse, which could be a potential target for cancer therapy.

Key words: Neoplasms, MicroRNAs, RNA-binding proteins, Neoplastic stem cells

彭景涛, 莫仁, 凡杰. 双向负反馈环路lin28-let-7与肿瘤[J]. 国际肿瘤学杂志, 2014, 41(3): 165-168.

PENG Jing-Tao, MO Ren, FAN Jie. A double-negative feedback loop lin28-let-7 and tumor[J]. Journal of International Oncology, 2014, 41(3): 165-168.

参考文献

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