国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 566-569.

• 综述 • 上一篇    下一篇

SOX1与肿瘤

张嘉良, 关中   

  1. 510120广东广州 中山大学孙逸仙纪念医院耳鼻喉头颈外科
  • 出版日期:2013-08-08 发布日期:2013-08-15
  • 通讯作者: 关中，dr_guanzhong@126.com E-mail:dr_guanzhong@126.com

SOX1 and tumors

ZHANG  Jia-Liang, GUAN  Zhong   

  1. Ear-Nose-Throat Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
  • Online:2013-08-08 Published:2013-08-15
  • Contact: Corresponding author：GUAN Zhong, E-mail: dr_guanzhong@126.com E-mail:dr_guanzhong@126.com

PDF

1398

被引次数

1

摘要： SOX1是转录因子SOX家族中的一员，具有调控神经系统及晶状体发育等作用。SOX1在肿瘤中的作用日渐引起了人们注意。研究表明，SOX1在多种肿瘤组织中因甲基化水平上升而呈低表达，能够调控肿瘤的增殖、侵袭与转移能力，且在调节肿瘤干细胞的分化过程中起着重要的作用。深入研究SOX1及其在相关信号通路中的作用，可为肿瘤治疗提供新途径。

关键词: 肿瘤, SOX1蛋白

Abstract: SOX1, a member of the SOX transcript factor super family, has been demonstrated having the functions of regulating the development of human embryonic neural system and crystalline lens, and the additional function of SOX1 in tumors are attracting more and more attention as well. It is reported in resent years that SOX1 is detected low expressed in many kinds of tumor issue, which owns to the methylation of SOX1. SOX1 can also regulate the abilities of tumors on proliferation, invasion and migration. Besides, SOX1 may play a crucial role in regulation of the differentiation of cancer stem cells. Further research of SOX1 and its function among related pathways may contribute to seeking for new therapies for tumor treatment.

Key words: Neoplasms, SOX1 protein