国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 469-471.

• 综述 • 上一篇    下一篇

光敏剂药物运载体系在光动力治疗肿瘤中的应用

涂庆峰, 王秀丽, 石磊, 王宏伟   

  1. 200050 安徽医科大学上海皮肤病临床学院暨上海市皮肤病医院（涂庆峰、王秀丽、石磊）；复旦大学附属华东医院皮肤科（王宏伟）

  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 王宏伟，E-mail：hongweiwang2005@yahoo.com.cn E-mail:hongweiwang2005@yahoo.com.cn
  • 基金资助:

    上海市自然科学基金（11ZR1432800）；上海市卫生系统优秀人才培养计划（XBR2011059）

Application of photosensitizer drug delivery system in photodynamic therapy of tumors

TU  Qing-Feng, WANG  Xiu-Li, SHI  Lei, WANG  Hong-Wei   

  1. Dematology Hospital & Shanghai Clinical Institute of Skin Disease, Anhui Medical University, Shanghai 200050, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: WANG Hong-Wei E-mail:hongweiwang2005@yahoo.com.cn

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摘要： 诸多体内外实验证明，通过运用适宜的药物运载体系既可以增加光敏剂的稳定性，也可以促进光敏剂在肿瘤组织中聚集，提高光动力治疗的靶向性，加深其作用深度和单态氧的产出率，并能减少不良反应。所以新型光敏剂药物运载体系的研究在光动力治疗肿瘤中拥有重要的应用价值。

关键词: 光动力疗法, 光敏感药, 药物载体, 肿瘤

Abstract: In vitro or in vivo results of investigations into the development of photosensitizer drug delivery systems have demonstrated that the use of vehicles not only enhance the stability of photosensitizer, but also promote the accumulation of photosensitizer in tumor tissue, enhance the targetability of photodynamic therapy, the working depth, the yield of singlet oxygen and overcome many untoward effects. So the research of new photosensitizer drug delivery system has important application value in photodynamic therapy of tumor.

Key words: Photodynamic therapy, Photosensitizer, Drug carriers, Neoplasms