国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 342-344.

• 综述 • 上一篇    下一篇

他汀类药物抗肿瘤作用机制

苏克莉, 尹林林, 李静   

  1. 250031济南市第四人民医院肿瘤科
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 基金资助:

    济南市卫生局科技计划(2009-41)

Anti-tumor effects of statins

SU  Ke-Li, YIN  Lin-Lin, LI  Jing   

  1. Department of Oncology, Fourth People's Hospital of Jinan, Jinan 250031, China
  • Online:2013-05-08 Published:2013-05-15

摘要: 他汀类药物除有降胆固醇作用外,还对恶性肿瘤有一定的治疗作用。其可能的抗肿瘤作用机制为:诱导细胞凋亡及分化、抑制肿瘤细胞增殖、降低肿瘤细胞侵袭转移能力、联合增敏以及化学预防作用。

关键词: 肿瘤, 治疗应用, 他汀类药物

Abstract: Statins not only can help lower cholesterol, but also has certain effect for the treatment of malignant tumor. Its possible antitumor mechanisms include inducing apoptosis and differentiation, inhibiting tumor cell proliferation, reducing the invasion and metastasis of tumor cells, combined sensitization and chemical prevention effect.

Key words: Neoplasms, Therapeutic uses, Statins