国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 748-751.

• 综述 • 上一篇    下一篇

减毒沙门菌在肿瘤基因治疗中应用

李鹏飞, 孙君重   

  1. 100039 北京，解放军总医院第一附属医院肿瘤科
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 孙君重，E-mail：sjunzh07@163.com E-mail:sjunzh07@163.com
  • 基金资助:

    国家自然科学基金（81071839）

Application of attenuated salmonella in the gene treatment of tumor

LI  Peng-Fei, SUN  Jun-Zhong   

  1. Department of Oncology, First Affiliated Hospital of General Hospital of PLA, Beijing 100039, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: SUN Jun-zhong, E-mail: sjunzh07@163.com E-mail:sjunzh07@163.com

PDF

1289

摘要： 沙门菌是一类胞内侵袭性兼性厌氧菌，减毒后仍保留其抗原性，现在广泛作为DNA疫苗的载体。沙门菌携带相关抗原基因对多种肿瘤有显著的抑制效果，而且携带修复基因对放化疗后的机体损伤有着明确的修复作用。

关键词: 减毒沙门菌, 肿瘤, 疫苗载体, 损伤修复

Abstract: Salmonella is a kind of intracellular invasive facultative anaerobe, maintaining its antigenicity after being attenuated. Now, it has been widely used as a  transporter of DNA vaccines. Salmonella carrying related antigen gene can inhibit multiple tumors, and salmonella carrying repair gene has a clear repair effect for the organism injury after chemoradiotherapy.

Key words: Attenuated salmonella, Neoplasms, Vaccine carrier, Damage repairment