国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 745-748.

• 综述 • 上一篇    下一篇

外周血基因表达谱在肿瘤诊断中的应用

李萌硕, 陈俊辉   

  1. 518036 深圳,北京大学深圳医院微创介入科(李萌硕、陈俊辉);515041 汕头大学医学院研究生部(李萌硕)
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 陈俊辉,E-mail:chenjhpush@126.com E-mail:chenjhpush@126.com
  • 基金资助:

    深圳市科技研发资金项目(JCYJ20120831144704366)

Application of peripheral blood gene expression profiling in cancer diagnosis

LI  Meng-Shuo, CHEN  Jun-Hui   

  1. Department of Mini-invasive Interventional Radiology, Shenzhen Hospital, Peking University, Shenzhen 518036; Department of Postgraduate, Medical College of Shantou University, Shantou 515041, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: CHEN Jun-hui, E-mail: chenjhpush@126.com E-mail:chenjhpush@126.com

摘要: 外周血基因表达谱代表了外周血细胞所有基因表达的格局。通过比较肿瘤患者与健康对照者以及不同种类肿瘤患者之间外周血基因表达的不同,可以得出差异表达基因,从而进一步分析其特征性基因表达谱进行辅助诊断和治疗。目前,外周血基因表达谱已在头颈部肿瘤、胸部肿瘤、腹腔肿瘤、泌尿及男生殖系肿瘤、妇科肿瘤等多种肿瘤领域研究成果显著,给未来临床应用奠定了基础。

关键词: 基因表达谱, 血液, 肿瘤, 诊断

Abstract: Peripheral blood gene expression profiling represents the pattern of expression of all genes in peripheral blood cells. By comparing the different gene expression of peripheral blood in cancer patients and healthy control or patients with alternative types of tumors, we can draw genes of different expression and further analyze the characteristic gene expression profiling to assist diagnosis and treatment. There have been remarkable advance in study of peripheral blood gene expression profiling in head and neck tumors, chest tumors, abdominal tumors, urinary tract and male reproductive system tumors, gynecological tumors and so on, which lay a foundation for further clinical applications.

Key words: Gene expression profiling, Blood, Neoplasms, Diagnosis