国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 732-735.

• 综述 • 上一篇    下一篇

NNMT基因在肿瘤中的研究

周伟敏, 钟狂飚, 桂明   

  1. 410013 长沙 中南大学湘雅三医院泌尿外科

  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 钟狂飚，E-mail:zkbgm@126.com E-mail:zkbgm@126.com

Research about NNMT gene in cancer

ZHOU  Wei-Min, ZHONG  Kuang-biao, GUI  Ming   

  1. Department of Urology, Third Xiangya Hospital, Central South University, Changsha 410013, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: ZHONG Kuang-biao E-mail:zkbgm@126.com

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摘要： 烟酰胺N-甲基转移酶（NNMT）是一种S-腺苷-L蛋氨酸（SAM）依赖性胞质酶，在多种药物和异型生物质的生物转化和解毒中起重要作用。近年来研究发现，NNMT在多种肿瘤中异常表达，可能与肿瘤的发生、发展以及放化疗抵抗密切相关。

关键词: 烟酰胺N-甲基转移酶, 烟酰胺, 肿瘤

Abstract: Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-L-methionine (SAM) dependent cytoplasm enzyme, which plays a vital role in the biotransformation and detoxification of many drugs and xenobiotic compounds. Recent studies have revealed abnormal expression of NNMT in many tumors, which may contribute to tumorigenesis and tumor development and radiotherapy or chemotherapy resistance.

Key words: Nicotinamide N-methyltransferase, Nicotinamide, Neoplasms