国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 286-288.

• 综述 • 上一篇    下一篇

血管内皮生长因子与肺癌的治疗和预后

赵求, 郭人花   

  1. 210029 南京医科大学第一附属医院肿瘤科
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 郭人花, E-mail: rhguo@njmu.edu.cn E-mail:rhguo@njmu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目(81172217)

VEGF in the treatment and prognosis of lung cancer

ZHAO  Qiu, GUO  Ren-Hua   

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: GUO Ren-hua, E-mail: rhguo@njmu.edu.cn E-mail:rhguo@njmu.edu.cn

摘要: 在肺癌生长和转移的过程中,新生血管的生成能够促进肿瘤的生长和转移。血管内皮生长因子(VEGF)是目前已知最强的促血管生成因子,因此,抗VEGF治疗能够通过抑制新生血管的生成而成为肺癌靶向治疗的一种重要形式,同时,VEGF的表达对肺癌预后的判断同样有着重要意义。

关键词: 血管内皮生长因子类, 肺肿瘤, 预后

Abstract:  Angiogenesis plays a critical role in growth and metastasis of lung cancer. The strongest tumor angiogenesis factor known is the vascular endothelial growth factor (VEGF). Therefore, anti-VEGF therapy which can restrain tumor angiogenesis is an important form of the targeted therapy of lung cancer. The expression of VEGF is also significant to the prognosis of lung cancer.

Key words: Vascular endothelial growth factors, Lung neoplasms, Prognosis