国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 282-285.

• 综述 • 上一篇    下一篇

微小RNA与非小细胞肺癌

何艳, 刘宜敏   

  1. 510120 广州，中山大学孙逸仙纪念医院放疗科
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 刘宜敏，E-mail：liuyimincn@139.com E-mail:liuyimincn@139.com
  • 基金资助:

    广东省科技计划项目（2009B03081119）

miRNA and non-small cell lung cancer

HE  Yan, LIU  Yi-Min   

  1. Department of Radiotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong 510120, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: LIU Yi-min, E-mail: liuyimincn@139.com E-mail:liuyimincn@139.com

PDF

1771

被引次数

4

摘要： 微小RNA（miRNA）是真核细胞中一大类参与基因转录后调控的非编码小分子RNA，研究表明miRNA与非小细胞肺癌（NSCLC）发生发展密切相关。在NSCLC中，miRNA通过下调抑癌基因，作为癌基因或作用于信号通路中某些靶点，其累积最终可能导致肺癌细胞生物学效应的明显改变，从而被认为与其发生，肿瘤细胞增殖及侵袭，细胞凋亡及放化疗抵抗性的获得等有关。因此，miRNA将有希望用于肿瘤的诊断及治疗。

关键词: 癌, 非小细胞肺, 微RNAs

Abstract: MicroRNAs (miRNAs) are a class of small non-coding RNAs which involve in the regulation after gene transplantation. Researches show that miRNA is closely related to the development and progression of non–small-cell lung cancer (NSCLC). They caused a significantly change in NSCLC cells through downregulate tumor suppressor gene, or act as oncogene or work on some targets which is important in cell signal pathway, in the end it lead to oncogenesis, cell proliferation, cell apoptosis and resistance to chemotherapy or radiotherapy. Therefore, miRNA will be hopefully used in the diagnose and therapy of cancer.

Key words: Carcinoma, non-small-cell lung, MicroRNAs