国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 806-808.

• 综述 • 上一篇    下一篇

人食管癌相关基因4与肿瘤

洪超群, 游颜杰, 黄继红   

  1. 515041 汕头大学医学院附属肿瘤医院（洪超群、黄继红）；汕头大学医学院肿瘤研究中心（游颜杰）
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 通讯作者: 游颜杰， E-mail: youyanjie@163.com E-mail:youyanjie@163.com
  • 基金资助:

    广东省医学科研基金资助项目（B2012261）

Esophageal cancer related gene 4 in tumor

HONG  Chao-Qun, YOU  Yan-Jie, HUANG  Ji-Hong   

  1. Cancer Research Laboratory, Cancer Hospital of Shantou University Medical College, Shantou 515041, China
  • Online:2012-11-08 Published:2012-11-16
  • Contact: Corresponding author：YOU Yan-jie, E-mail:youyanjie@163.com E-mail:youyanjie@163.com

PDF

1868

被引次数

3

摘要： 人食管癌相关基因4（ECRG4）通过与NF-κB与p53相互作用参与调节细胞周期从而发挥抑癌基因的功能。研究表明ECRG4表达下调与多种肿瘤的发生发展密切相关，提示ECRG4有希望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点。

关键词: 基因, 肿瘤抑制, 肿瘤, 肿瘤标记, 生物学, 诊断

Abstract: Esophageal cancer related gene 4 (ECRG4) serves as a tumor suppressor gene through interacting with NF-κB and p53 pathways. Multiple studies have demonstrated that the down-regulated expression of ECRG4 occurs in a variety of cancer types, indicating a potential application of ECRG4 as a molecular diagnostic marker as well as a therapeutic target

Key words: font-size: 12pt">Genes, tumor suppressor, Neoplasms, Tumor markers, biological, Diagnosis