国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (1): 57-60.

• 综述 • 上一篇    下一篇

哺乳动物雷帕霉素靶蛋白信号通路与大肠癌

马慧, 刘延庆   

  1. 225000  扬州大学医学院中西医结合临床医学系肿瘤研究室
  • 出版日期:2012-01-08 发布日期:2013-11-11
  • 通讯作者: 刘延庆，E-mail：liuyq@yzu.edu.cn E-mail:liuyq@yzu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目81173603

mTOR signaling pathway and colorectal cancer

MA  Hui, LIU  Yan-Qing   

  1. Cancer Research Institute, Medical College of Integrated Traditional Chinese and Western Medicin, Yangzhou University, Yangzhou 225000, China

  • Online:2012-01-08 Published:2013-11-11
  • Contact: Corresponding author: LIU Qing-yan, E-mail: liuyq@yzu.edu.cn E-mail:liuyq@yzu.edu.cn

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被引次数

4

摘要： 哺乳动物雷帕霉素靶蛋白（mTOR）信号通路作为细胞内重要信号转导通路之一，通过影响下游多种效应分子的活化状态，调节细胞存活、增殖、转分化、迁移和细胞周期。mTOR这些调节机制的异常与大肠癌的发生和发展密切相关。目前mTOR抑制剂治疗大肠癌已处于临床试验中，并取得了一定的进展。

关键词: 结直肠肿瘤, mTOR信号通路, mTOR抑制剂

Abstract: Mammalian target of rapamycin (mTOR) signaling pathway, one of the most important cellular signaling transduction pathways, regulates cell survival, proliferation, transdifferentiation, migration and cell cycle by influencing the activation state of various effector molecules in the downstream. Abnormal regulations of these machanisms are closely related to the tumorigenesis and progression of colorectal cancer (CRC). Currently, mTOR inhibitors have been approved in clinical trials of CRC and have made some progress.