国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (8): 620-623.

• 综述 • 上一篇    下一篇

直肠癌新辅助放化疗后的非手术治疗

张海芹, 王仁本   

  1. 山东省肿瘤医院放疗科
  • 出版日期:2011-08-08 发布日期:2011-08-29
  • 通讯作者: 张海芹 E-mail:sunshine_715@126.com

Considerations in rectal cancer after neoadjuvant chemoradiotherapy for wait and see

ZHANG  Hai-Qin, WANG  Ren-Ben   

  • Online:2011-08-08 Published:2011-08-29
  • Contact: Hai-Qin ZHANG E-mail:sunshine_715@126.com

摘要: 新辅助放化疗目前已成为临床Ⅱ、Ⅲ期直肠癌的标准辅助治疗方式。接受新辅助治疗的患者部分可达到病理完全缓解,即切除的样本中不存在癌细胞。Habr-Gama筛选出达到临床完全缓解的患者取消手术治疗后仍获得较好的生存率。因此临床是否可以通过筛选取消部分患者的手术治疗,以避免术中及术后可能存在的风险及不良反应成为值得探讨的问题。本文通过对非手术治疗的提出及患者的筛选进行综述。

关键词: 直肠肿瘤, 新辅助治疗, 非手术治疗

Abstract: Neoadjuvant chemoradiotherapy has been used as a standard treatment for patients with locally advanced (T3 and T4) rectal carcinoma. A proportion of the patients received neoadjuvant chemoradiotherapy present with a pathological complete response (pCR), an entity defined as absence of any tumor cell. In Habr-Gama's reseach, immediate surgery was avoided by for highly selected patients. Those patients who sustained a complete clinical response(cCR) for at least 12months did no worse than those who had surgery over the same period of time with no residual cancer at pathological evaluation.Further researches are still needed to investigate whether it is safe to avoid and just wait and see for highly selected patients.

Key words: Rectal neoplasms, Neoadjuvant therapy, Wait and see