青蒿素及其衍生物抗肿瘤作用及其分子机制

doi:10.3760/cma.j.issn.1673422X.2016.12.012

摘要/Abstract

摘要： 青蒿素及其衍生物是治疗疟疾的首选药，近年来大量体内外研究显示青蒿素及其衍生物具有良好的抗肿瘤活性，其抗肿瘤机制主要包括氧化损伤反应、抑制肿瘤细胞增殖以及抗新生血管生成等。青蒿素类药物不良反应小、成本较低，对多药耐药细胞有效，对放化疗具有增效作用，可能成为具有临床应用价值的抗癌新药。

关键词: 青蒿素, 抗肿瘤药, 药理作用分子作用机制

Abstract: Artemisinin and its derivatives are the first choices for the treatment of malaria medicine. In recent years, a large number of studies in vivo and in vitro show that artemisinin and its derivatives have good antitumor activities. Its antitumor mechanism mainly includes the oxidation damage reaction, inhibiting tumor cell proliferation and resistance to new angiogenesis. Artemisinin and its derivatives have little side effect, low cost, effective aginst multidrugresistant cell and a synergistic effect on radiotherapy and chemotherapy, which may become promising clinical anticancer compounds.

Key words: Artemisinin, Antineoplastic agents, Molecular mechanisms of pharmacological action

辛重阳, 王宝成, 王俊. 青蒿素及其衍生物抗肿瘤作用及其分子机制[J]. 国际肿瘤学杂志, 2016, 43(12): 927-929.

XIN Zhong-Yang, WANG Bao-Cheng, WANG Jun. Antitumor effect and its molecular mechanism of artemisinin and its derivatives[J]. Journal of International Oncology, 2016, 43(12): 927-929.

参考文献

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