国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (12): 915-917.doi: 10.3760/cma.j.issn.1673422X.2016.12.008

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肿瘤的表观遗传学研究进展

张凯丽, 叶芳   

  1. 山西医科大学第二医院血液科
  • 出版日期:2016-12-08 发布日期:2016-11-02

Advances of epigenetics studys in malignant tumors

ZHANG  Kai-Li, YE  Fang   

  1. Department of Hematology, The Second Hospital, Shanxi Medical University, Taiyuan 030001, China
  • Online:2016-12-08 Published:2016-11-02

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摘要： 表观遗传学是不涉及基因序列变化而发生的基因表达水平的改变，并且这种变化是可逆的。表观遗传学主要包括DNA甲基化、组蛋白修饰、非编码RNA调控、染色质重塑。随着对表观遗传学的深入研究，其在恶性肿瘤发生发展中的作用已得到认可。

关键词: 肿瘤, DNA甲基化, 组蛋白密码

Abstract: Epigenetics occurs in the level of gene expression without disorder of gene sequences, and such changes are reversible. The main contents of epigenetics include DNA methylation, histone modification and non encoding RNA regulation, chromatin remodeling. With the further study of epigenetics, its role in the occurrence and development of malignant tumor has been recognized.

Key words: Neoplasms, DNA methylation, Histone code