国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (3): 188-191.doi: 10.3760/cma.j.issn.1673422X.2015.03.007

• 综述 • 上一篇    下一篇

泛素化及其在肿瘤中的作用

高孝家, 杨慧, 吴林, 周福祥, 周云峰   

  1. 430071 武汉大学中南医院放化疗科,国家临床重点专科,湖北省肿瘤医学临床研究中心,肿瘤生物学行为湖北省重点实验室
  • 出版日期:2015-03-08 发布日期:2015-01-29
  • 通讯作者: 周云峰，Email: yfzhouwhu@163．com E-mail:yfzhouwhu@163．com

Ubiquitin and its role in the tumor

 GAO  Xiao-Jia, YANG  Hui, WU  Lin, ZHOU  Fu-Xiang, ZHOU  Yun-Feng   

  1. Department of Radiation and Chemotherapy, Zhongnan Hospital of Wuhan University, State Key Clinical Specialty, Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behavior, Wuhan 430071, China
  • Online:2015-03-08 Published:2015-01-29
  • Contact: Zhou Yunfeng E-mail:yfzhouwhu@163．com

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被引次数

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摘要： 泛素化过程是内源性蛋白质降解的主要途径之一，因此参与泛素化过程的泛素交联酶UbE2D3会影响细胞内某些蛋白及核酸的含量、活性进而影响其生物效应。在肿瘤细胞中，这种作用显得尤其关键，可参与部分癌症因子的修饰与降解，从而影响肿瘤的生物学行为。研究表明，在乳腺癌中UbE2D3与人类端粒酶逆转录酶(hTERT)、放射敏感性、侵袭性等相关。

关键词: 泛素化, 肿瘤, 辐射耐受性, 泛素蛋白连接酶D3, 人类端粒酶逆转录酶

Abstract: Ubiquitinproteasome pathway is one of the primary pathway in intracellular protein degradation, therefore the ubiquitin conjugating enzyme D3 (UbE2D3) which involved in the ubiquitin mineralization process can affect the biological effects accordingly to affect some protein and nucleic acid content and activity. The function that participate in modification and degradation of some cancer factors is vital in tumor cells, and followed by tumor biological behavior changing. Researches show that UbE2D3 correlates with human telomerase reverse transcriptase (hTERT), radiation sensitivity, aggressive, etc in breast cancer.

Key words: Ubiquitination, Neoplasms, Radiation tolerance, Ubiquitinconjugating enzyme E2D3, Human telomerase reverse transcriptase