国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 290-293.doi: 10.3760/cma.j.issn.1673422X.2014.04.016

• 综述 • 上一篇    下一篇

微小RNA与结直肠癌

张灵敏, 王亚旭   

  1. 400010 重庆医科大学附属第二医院胃肠外科
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 王亚旭，Email: wangyaxu1967@aliyun.com E-mail:wangyaxu1967@aliyun.com

MicroRNAs and colorectal cancer

ZHANG  Ling-Min, WANG  Ya-Xu   

  1. Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Wang Yaxu E-mail:wangyaxu1967@aliyun.com

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1723

被引次数

3

摘要： 微小RNA(miRNA)在细胞生长、分化、凋亡和肿瘤发生中发挥重要的调控作用。研究显示，miRNA调控目的基因表达与结直肠癌的发生发展、化疗敏感性及预后密切相关。检测miRNA有望为结直肠癌患者制定更详细的个体化化疗方案，并改善其预后。

关键词: 微RNAs, 结直肠肿瘤, 抗药性, 肿瘤, 药物疗法, 预后

Abstract: MicroRNAs (miRNAs) are involved in cell growth, differentiation, apoptosis and tumor occurrence and play an important role in regulation. Many studies show that miRNAs can regulate the expression of target gene, which is associated closely with the occurrence, development, chemosensitivity and prognosis of colorectal cancer. Detection of miRNAs is expected to formulate more detailed individualized chemotherapy for colorectal cancer patients and improve their prognosis.

Key words: MicroRNAs, Colorectal neoplasms, Drug resistangce, neoplasm, Drug therapy, Prognosis