国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 251-254.doi: 10.3760/cma.j.issn.1673422X.2014.04.004

• 综述 • 上一篇    下一篇

自噬与肿瘤血管生成

赵嵌嵌, 张月英, 张维东   

  1. 250062 济南，山东省医学科学院基础医学研究所实验病理研究室；济南大学山东省医学科学院医学与生命科学学院
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 张维东 E-mail:zhangweidongkui@163.com
  • 基金资助:

    国家自然科学基金（81073102）

Autophagy and vascularization

ZHAO  Qian-Qian, ZHANG  Yue-Ying, ZHANG  Wei-Dong   

  1. Pathology Laboratory, Institute of Basic Medicine, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Ji′nanShandong Academy of Medical Sciences, Ji′nan 250062, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Zhang Weidong E-mail:zhangweidongkui@163.com

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被引次数

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摘要： 自噬调节的分子机制十分复杂，常从多个层面影响肿瘤的发生发展，已成为病理学研究的热点。血管生成包括病理性血管生成和生理性血管生成，肿瘤组织中的新生血管为不断浸润生长的原发肿瘤提供营养，与肿瘤的发展和转移密切相关。通过调节内皮细胞的自噬可以直接影响血管生成过程，为肿瘤治疗提供了新的方向。

关键词: 自噬, 肿瘤, 新生血管化, 病理性

Abstract: The molecular mechanism of autophagy is complicated and it always affects the occurrence and development of tumor in many different degrees, so it is the new hot spot in pathological study area. The angiogenesis includes physiological vascularization and pathological vascularization, and the pathological new vessels which provide nutrition for the continuous growth of tumors have a close relationship to the development and metastasis of tumor. The process of angiogenesis can be affected by regulating the autophagy of vascular endothelial cells, which provides a new method for tumor therapy.

Key words: Autophagy, Neoplasms, Vascularization, pathologic