转移性三阴性乳腺癌临床研究现状

doi:10.3760/cma.j.issn.1673-422X.2020.03.008

摘要/Abstract

摘要：

三阴性乳腺癌(TNBC)复发风险高,预后差。转移性三阴性乳腺癌(mTNBC)的中位生存期约为1年。目前,mTNBC主要治疗手段仍然是细胞毒化疗。近年来,有关mTNBC的临床研究涉及的药物包括聚ADP核糖聚合酶抑制剂、磷脂酰肌醇3-激酶途径抑制剂、靶向表皮生长因子受体抗体、靶向滋养层细胞表面抗原-2抗体、靶向死亡受体5抗体、针对雄激素受体的内分泌治疗药物、免疫检查点抑制剂等。新的药物已经逐步改善mTNBC患者的生存。

关键词: 三阴性乳腺癌, 肿瘤转移, 临床试验, 综述

Abstract:

Triple negative breast cancer (TNBC) is associated with a high risk of recurrence and generally a poor prognosis. Median survival time of metastatic triple negative breast cancer (mTNBC) is about one year. Currently, the mainstay of treatment for mTNBC remains cytotoxic chemotherapy. In recent years, the drugs involved in the clinical researches of mTNBC include poly-ADP-ribose polymerase inhibitors, phosphoinositide 3-kinase pathway inhibitors, antibody targeting epidermal growth factor receptor, antibody targeting trophoblast surface antigen-2, antibody targeting death receptor 5, endocrine therapy drugs for androgen receptor, and immune checkpoint inhibitors and so on. New drugs have gradually improved the survival of patients with mTNBC.

Key words: Triple negative breast neoplasms, Neoplasm metastasis, Clinical trial, Review

李开春, 王雅杰. 转移性三阴性乳腺癌临床研究现状[J]. 国际肿瘤学杂志, 2020, 47(3): 169-173.

Li Kaichun, Wang Yajie. Current status of clinical researches on metastatic triple negative breast cancer[J]. Journal of International Oncology, 2020, 47(3): 169-173.

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