国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (4): 250-252.doi: 10.3760/cma.j.issn.1673-422X.2018.04.015

• 综述 • 上一篇    下一篇

Notch信号通路在肺癌和肺癌干细胞中的作用及其抑制剂

刘恒铫,赵国丽,王福文,蔡海波,张月英   

  1. 250200 济南大学 山东省医学科学院医学与生命科学学院(刘恒铫、赵国丽)；山东省医学科学院药物研究所 国家卫生和计划生育委员会生物技术药物重点实验室 山东省罕少见病重点实验室(刘恒铫、王福文)；山东省医学科学院基础医学研究所病理学与病理生理学研究室(赵国丽、张月英)；济宁市第一人民医院胸外科（蔡海波）
  • 出版日期:2018-04-08 发布日期:2018-05-16
  • 通讯作者: 张月英，Email: zhangyueying828@126.com E-mail:zhangyueying828@126.com
  • 基金资助:

    国家自然科学基金（81403150）；山东省自然科学基金（ZR2014HL064）；山东省中医药科技发展计划（2015325）；山东省医学科学院医药卫生科技创新工程

Notch signaling pathway in lung cancer and lung cancer stem cells and its inhibitors

Liu Hengyao, Zhao Guoli, Wang Fuwen, Cai Haibo, Zhang Yueying.   

  1. School of Medicine and Life Sciences, University of Ji′nanShandong Academy of Medical Sciences; Institute of Materia Medica, Shandong Academy of Medical Sciences; Key Laboratory for BiotechDrugs of National Health and Family Planning Commission; Key Laboratory for Rare ＆ Uncommon Diseases of Shandong Province, Ji′nan 250200, China
  • Online:2018-04-08 Published:2018-05-16
  • Contact: Zhang Yueying, Email: zhangyueying828@126.com E-mail:zhangyueying828@126.com
  • Supported by:

    National Natural Science Foundation of China (81403150); Natural Science Foundation of Shandong Province of China (ZR2014HL064); Development Project of Traditional Chinese Medical Sciences and Technology of Shandong Province (2015325); Innovation Project of Shandong Academy of Medical Sciences

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摘要： Notch信号通路参与肺癌干细胞的异常分化和自我更新，深入研究Notch信号通路在肺癌干细胞调控中的作用，有望在肺癌的诊断及治疗中找到新的靶点。作用于Notch信号通路的抑制剂可能成为有效治疗肺癌的药物。肺癌干细胞被认为是肺癌复发的主要因素，因此针对肺癌干细胞的靶向治疗可能比针对整个肿瘤的治疗更有效。

关键词: 受体, Notch, 肺肿瘤, 肿瘤干细胞, 抑制剂

Abstract: Notch signaling pathway is involved in the abnormal differentiation and selfrenewal of lung cancer stem cells. The further studies for the roles of Notch signaling pathway in the regulation of lung cancer stem cells are expected to find new targets in the diagnosis and treatment of lung cancer. Inhibitors of the Notch signaling pathway may be effective in the treatment of lung cancer. Lung cancer stem cells are thought to be a major cause of recurrence of lung cancer, therefore, targeted therapy for lung cancer stem cells may be more effective than treatment for the entire tumor.

Key words: Receptors, Notch, Lung neoplasms, Neoplastic stem cells, Inhibitors