国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (6): 445-.doi: 10.3760/cma.j.issn.1673-422X.2017.06.011

• 综述 • 上一篇    下一篇

miR-151-5p在肿瘤中的研究进展

柯建波,凌志强,赏金标   

  1. 310000 杭州,浙江中医药大学第二临床医学院(柯建波);浙江省肿瘤医院肿瘤研究所(凌志强),头颈肿瘤外科(赏金标)
  • 出版日期:2017-06-08 发布日期:2017-06-16
  • 通讯作者: 赏金标 E-mail:shangjb@zjcc.org.cn
  • 基金资助:

    浙江省自然科学基金(Y15H160031)

Research progress of miR-151-5p in tumor

Ke Jianbo, Ling Zhiqiang, Shang Jinbiao   

  1. Second Clinical Medical School of Zhejiang Traditional Chinese Medicine University, Hangzhou 310000, China
  • Online:2017-06-08 Published:2017-06-16
  • Contact: Shang Jinbiao E-mail:shangjb@zjcc.org.cn
  • Supported by:

    Natural Science Foundation of Zhejiang Province of China (Y15H160031)

摘要: 微小RNA(miRNA)在转录后水平对基因表达进行负性调控。研究发现miR1515p在人体多种肿瘤中异常表达,可能在其发展过程,特别是浸润和转移中起重要作用。进一步研究miR1515p有助于更深入地认识某些肿瘤的浸润和转移机制,对肿瘤诊断、治疗和预后有着潜在的重要价值。

关键词: 基因表达调控, 肿瘤侵润, 肿瘤转移, miR-151-5p

Abstract: MicroRNA (miRNA) negatively regulates gene expression at the posttranscriptional level. Studies find that the abnormal expression of miR1515p in various human tumors may play an important role in the development of human tumors, especially in the invasion and metastasis. Further studies of miR1515p contribute to a more indepth understanding of tumor invasion and metastasis, which have potential value in tumor diagnosis, treatment and prognosis.

Key words: Gene expression regulation, Neoplasm invasiveness, Neoplasm metastasis, miR-151-5p