国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (5): 398-400.doi: 10.3760/cma.j.issn.1673-422X.2014.05.024

• 情报信息 • 上一篇    

Gene Expression Omnibus资源库在肿瘤学研究中的应用

董晓蒙,王宜强   

  1. 266071 青岛大学医学院免疫教研室（董晓蒙、王宜强）；苏州大学附属第一医院 江苏省血液研究所 卫生部血栓与止血重点实验室（王宜强）
  • 收稿日期:2014-01-17 修回日期:2014-03-05 出版日期:2014-05-08 发布日期:2014-04-28
  • 通讯作者: 王宜强 E-mail:yiqiangwang99@hotmail.com
  • 基金资助:

    江苏省科教兴卫工程-临床医学中心资助项目（ZX201102）

Application of Gene Expression Omnibus in oncology

Dong Xiaomeng, Wang Yiqiang   

  1. Department of Immunology, Qingdao University Medical College, Qingdao 266071, China
  • Received:2014-01-17 Revised:2014-03-05 Online:2014-05-08 Published:2014-04-28
  • Contact: Wang Yiqiang E-mail:yiqiangwang99@hotmail.com

PDF

1867

摘要： Gene Expression Ominibus（GEO）是供学者们分享基因表达谱芯片数据、高通量测序数据等的国际化的公共资源平台，其中涵盖了应用炎癌模型获得的大量相关实验数据，比如关于某些炎性因子的表达情况。这些数据为炎癌转化中的调控网络和分子机制的研究提供了帮助，也为肿瘤的防治提供了新思路。研究者针对新的预测基因进行研究时，起源于各种疾病模型或实验处理的GEO数据库为寻找其有关功能提供了有利条件和有力证据。

关键词: 基因表达, 炎症, 肿瘤, Gene Expression Omnibus

Abstract: Gene Expression Omnibus (GEO)can act as an international public resource platform storing and sharing experimental data generated from highthroughout research projects that utilize genomewide expression strategies like microarray screening and analysis. Numerous data involving inflammatory carcinoma models is helpful for dissecting the regulatory network and molecular mechanism of oncogenesis, thus offering favorable clues for new thoughts in prevention and treatment of cancers. GEO originated from various disease models or processed experiments also provides researchers with powerful evidence for tracing functions of novel predictive genes.

Key words: Gene expression, Inflammation, Neoplasms, Gene Expression Omnibus