结直肠癌发生的分子病理学基础

doi:10.3760/cma.j.issn.1673-422X.2014.05.011

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (5): 353-357.doi: 10.3760/cma.j.issn.1673-422X.2014.05.011

结直肠癌发生的分子病理学基础

蒋伟国,黄尤光

660101西双版纳农垦医院普外科（蒋伟国）；650106 昆明医科大学第三附属医院肿瘤研究所(蒋伟国、黄尤光)

收稿日期:2013-11-22 修回日期:2013-12-25 出版日期:2014-05-08 发布日期:2014-04-28
通讯作者: 黄尤光 E-mail:huangyouguang2008@126.com
基金资助:
云南省应用基础研究计划（2011FZ108）；云南省卫生科技计划（2012WS0040）

Basis of molecular pathology in colorectal carcinogenesis

Jiang Weiguo, Huang Youguang

Department of General Surgery, Land Reclamation Hospital of Xishuangbanna, Xishuangbanna 650101; Cancer Research Institute, Third Affiliated Hospital of Kunming Medical University, Kunming 650106, China

Received:2013-11-22 Revised:2013-12-25 Online:2014-05-08 Published:2014-04-28
Contact: Huang Youguang E-mail:huangyouguang2008@126.com

摘要/Abstract

摘要： 结直肠癌发生是遗传学和表观遗传学改变累积的结果。基因组不稳定导致基因突变和DNA甲基化模式改变是结直肠癌发生的主要分子事件。鉴定不同患者中导致结直肠癌发生的关键基因突变及甲基化表型，对结直肠癌进行分子病理分型和诊断，是进行个体化治疗和靶向治疗的前提。

关键词: 结直肠肿瘤, 基因, 突变, 甲基化

Abstract: Colorectal carcinogenesis is the result of accumulation of genetic and epigenetic alters. Gene mutations and changes in DNA methylation patterns, resulted from genomic instability, are the main molecular events in colorectal cancer. Identification of key mutations and methylation phenotypes in genes leading to colorectal cancer progression, and molecular pathology classification and diagnosis are likely to be the prerequisites for individualized and targeted treatment.

Key words: Colorectal neoplasms, Genes, Mutation, Methylation

蒋伟国,黄尤光. 结直肠癌发生的分子病理学基础[J]. 国际肿瘤学杂志, 2014, 41(5): 353-357.

Jiang Weiguo, Huang Youguang. Basis of molecular pathology in colorectal carcinogenesis[J]. Journal of International Oncology, 2014, 41(5): 353-357.

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结直肠癌发生的分子病理学基础

Basis of molecular pathology in colorectal carcinogenesis

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