上皮-间质转化及其干性作用与肿瘤

doi:10.3760/cma.j.issn.1673-422X.2013.12.006

摘要/Abstract

摘要： 上皮间质转化（EMT）参与肿瘤转移过程，Twist作为关键调控因子在EMT中发挥重要作用，放疗、化疗和多种细胞因子均可诱导Twist介导的EMT。研究表明，肿瘤细胞可能通过EMT转变为肿瘤干细胞样细胞，并进一步导致放化疗抵抗、肿瘤血管形成及远处转移，对肿瘤的预后产生巨大影响，EMT有望成为肿瘤治疗的重要靶点。

关键词: 细胞转化, 肿瘤, 肿瘤干细胞, Twist转录因子

Abstract: Epithelialmesenchymal transition (EMT) is a major mechanism in tumor metastasis. As the key regulatory factor, Twist gene plays an important role in EMT, and it can be induced by radiotherapy, chemotherapy and a variety of cytokines. Researches show that tumor cells can get stem celllike properties via EMT, which can lead to chemoradiotherapy resistance, tumor angiogenesis and distant metastasis. EMT has a great influence on the prognosis of tumor, and it is expected to become an important target for tumor treatment.

Key words: Cell transformation, neoplastic, Neoplastic stem cells, Twist transcription factor

邓春燕, 谭晓琴, 李涛, 黄建鸣. 上皮-间质转化及其干性作用与肿瘤[J]. 国际肿瘤学杂志, 2013, 40(12): 899-902.

DENG Chun-Yan, TAN Xiao-Qin, LI Tao, HUANG Jian-Ming. EMT mediated cancer stemness and tumor[J]. Journal of International Oncology, 2013, 40(12): 899-902.

参考文献

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