国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (5): 292-295.doi: 10.3760/cma.j.issn.1673422X.2018.05.009

• 综述 • 上一篇    下一篇

小眼畸形转录因子家族在肿瘤发生中的作用机制

庄文渊,甘卫东   

  1. 210000 南京大学附属鼓楼医院泌尿外科
  • 出版日期:2018-05-08 发布日期:2018-05-23
  • 通讯作者: 甘卫东,Email： gwd@nju.edu.cn E-mail:gwd@nju.edu.cn
  • 基金资助:

    国家自然科学基金（81572512）

Mechanism of microphthalmia family of transcription factors in tumorigenesis

Zhuang Wenyuan, Gan Weidong   

  1.  Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210000, China
  • Online:2018-05-08 Published:2018-05-23
  • Contact: Gan Weidong E-mail:gwd@nju.edu.cn
  • Supported by:

    National Natural Science Foundation of China (81572512)

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摘要： 小眼畸形转录因子家族（MiT/TFE）能够广泛调节肿瘤细胞增殖及能量代谢。该家族可以通过溶酶体相关基因的上调以及作用于氧化代谢及氧化应激反应这样的特异性靶点促进肿瘤的发生及发展。此外，MiT/TFE可以调节溶酶体的信号传导，其中包括哺乳动物雷帕霉素靶蛋白（mTORC1）通路和Wnt/βcatenin通路。而MiT/TFE和促卵泡激素基因(FLCN）的关系同样和肿瘤的进展密切相关。

关键词: 肿瘤, 溶酶体, 小眼畸形转录因子

Abstract: Microphthalmia family of transcription factors（MiT/TFE） is very important for the regulation of cancer cell proliferation and energy metabolism. The MiT/TFE promotes the genesis and development of tumors by upregulating the expression of lysosomal genes as well as acting on the oxidative metabolism and the oxidative stress response. MiT/TFE can also regulate lysosomal signaling including the mTORC1 and Wnt/βcatenin pathways. The relationship between MiT/TFE and folliculin (FLCN) is associated with the tumorigenesis.

Key words: Neoplasms, Lysosomes, Microphthalmia transcription factors