国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 635-637.doi: 10.3760/cma.j.issn.1673422X.2015.08.021

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胆道肿瘤的免疫治疗

刘秀峰,秦叔逵   

  1. 210002 南京，解放军第81医院肿瘤中心内四科
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 秦叔逵，Email: qinsk@csco.org.cn E-mail:qinsk@csco.org.cn

Immunotherapy of biliary tract cancer

 LIU  Xiu-Feng, QIN  Shu-Kui   

  1. Fourth Department of Oncology, Cancer Center of PLA, Nanjing 81st Hospital, Nanjing 210002, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Qin Shukui E-mail:qinsk@csco.org.cn

PDF

1336

被引次数

7

摘要： 胆道肿瘤(BTC)侵袭性强，早期诊断率仅为10%。研究显示，吉西他滨联合顺铂方案现已成为晚期BTC的标准一线化疗方案，但疗效仍不满意。免疫细胞的浸润以及免疫相关的微环境可以抑制多种不同类型的肿瘤。研究发现，肿瘤浸润性CD8+细胞毒T细胞和CD4+T细胞数量与BTC的预后密切相关，提示BTC的免疫治疗可能是一种新的手段。

关键词: 胆道肿瘤, 免疫疗法

Abstract: Biliary tract cancer (BTC) is one of the most aggressive malignancies with only 10% earlystage diagnosis rate. For advanced BTC, regimen of gemcitabine and cisplatin has been regarded as the first line standard combination, but the curative effect is still unsatisfied. Infiltration of immune cells and immunerelated microenvironment can inhibit various types of cancers. In BTC, higher frequencies of tumorinfiltrating CD8+ cytotoxic T cells and CD4+  T cells are closely associated with favorable prognosis. These findings have provided the rationale for further development of immunotherapies as a novel treatment modality against BTC.

Key words: Biliary tract neoplasms, Immunotherapy