国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 612-615.doi: 10.3760/cma.j.issn.1673422X.2015.08.014

• 综述 • 上一篇    下一篇

间充质干细胞介导的肿瘤治疗

 张洁,方琳,郑骏年   

  1. 221002 徐州医学院江苏省肿瘤生物治疗重点实验室
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 郑骏年，Email：jnzheng@xzmc.edu.cn E-mail:jnzheng@xzmc.edu.cn
  • 基金资助:

    国家自然科学基金（81372460）

Mesenchymal stem cellsbased cancer therapies

Zhang Jie, Fang Lin, Zheng Junnian   

  1. Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221002, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Zheng Junnian E-mail:jnzheng@xzmc.edu.cn

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摘要： 间充质干细胞(MSC)内在的肿瘤趋向性和固有的低免疫原性，使其可能成为肿瘤靶向治疗的理想载体。MSC本身可通过释放细胞因子发挥一定的抗肿瘤作用,而通过溶瘤病毒、抗血管生成药物、肿瘤坏死因子诱导凋亡配体、IL、IFN及前体药物修饰的MSC抗肿瘤效果进一步加强。另外，MSC联合其他治疗也显示出一定的优势。

关键词: 间充质干细胞, 肿瘤, 赋形剂

Abstract: Mesenchymal stem cells (MSCs) have inherent tumortrophic migratory properties and low immunogenicity, which allow them to serve as vehicles for delivering effective, targeted therapy to tumors. MSC plays an antitumor role by releasing some cytokines, which can be strengthened by oncolytic virus, antiangiogenesis agent, tumor necrosis factor guided apoptosis ligand, IL, IFN and prodrug. In addition, there are some advantages in combination treatment of MSC and others therapies.

Key words: Mesenchymal stem cells, Neoplasms, Vehicles