锰基纳米材料在乳腺癌诊疗中的应用进展

doi:10.3760/cma.j.cn371439-20240429-00108

摘要/Abstract

摘要：

乳腺癌是女性发病率最高的肿瘤，早期诊断并优化治疗策略对提高乳腺癌预后至关重要。近年来，随着纳米技术的发展，锰基纳米材料在乳腺癌早期诊断、药物递送、肿瘤治疗等多方面展现潜力。相较于其他纳米材料，锰基纳米材料具有良好的生物相容性，已成为乳腺癌诊疗研究中的重要方向。

关键词: 乳腺肿瘤, 纳米粒子, 磁共振成像, 肿瘤治疗方案

Abstract:

Breast cancer is the most common malignant tumor among women， and early diagnosis， coupled with optimized treatment strategies is crucial for improving the prognosis. In recent years， with the advancement of nanotechnology， manganese-based nanomaterials have shown potential in various aspects of early breast cancer diagnosis， drug delivery， and tumor treatment. Compared to other nanomaterials， manganese-based nanomaterials exhibit excellent biocompatibility and have become a significant focus in the research of breast cancer diagnosis and treatment.

Key words: Breast neoplasms, Nanoparticles, Magnetic resonance imaging, Antineoplastic protocols

陶晋, 阚俊楠, 杨彩霞, 刘岩, 吕奕洁, 魏俊辉, 李祥林. 锰基纳米材料在乳腺癌诊疗中的应用进展[J]. 国际肿瘤学杂志, 2024, 51(10): 645-649.

Tao Jin, Kan Junnan, Yang Caixia, Liu Yan, Lyu Yijie, Wei Junhui, Li Xianglin. Progress of manganese-based nanomaterials in breast cancer diagnosis and treatment[J]. Journal of International Oncology, 2024, 51(10): 645-649.

参考文献 37

[1]	赵倩雯, 彭丹莉, 秦韬, 等. 1990—2019年全球肿瘤发病死亡分析[J]. 国际肿瘤学杂志, 2023, 50(7): 425-431. DOI: 10.3760/cma.j.cn371439-20230315-00082.
[2]	Sun Z, Wang Z, Wang T, et al. Biodegradable MnO-based nanoparticles with engineering surface for tumor therapy: simultaneous fenton-like ion delivery and immune activation[J]. ACS Nano, 2022, 16(8): 11862-11875. DOI: 10.1021/acsnano.2c00969. pmid: 35925671
[3]	Jain P, Jangid AK, Pooja D, et al. Designing of manganese-based nanomaterials for pharmaceutical and biomedical applications[J]. J Mater Chem B, 2024, 12(3): 577-608. DOI: 10.1039/d3tb00779k.
[4]	Wekking D, Porcu M, De Silva P, et al. Breast MRI: clinical indications, recommendations, and future applications in breast cancer diagnosis[J]. Curr Oncol Rep, 2023, 25(4): 257-267. DOI: 10.1007/s11912-023-01372-x. pmid: 36749493
[5]	Chen X, Teng S, Li J, et al. Gadolinium(Ⅲ)-chelated deformable mesoporous organosilica nanoparticles as magnetic resonance imaging contrast agent[J]. Adv Mater, 2023, 35(20): 2211578. DOI: 10.1002/adma.202211578.
[6]	Daksh S, Kaul A, Deep S, et al. Current advancement in the development of manganese complexes as magnetic resonance imaging probes[J]. J Inorg Biochem, 2022, 237: 112018. DOI: 10.1016/j.jinorgbio.2022.112018.
[7]	Ouyang S, Chen C, Lin P, et al. Hydrogen-bonded organic frameworks chelated manganese for precise magnetic resonance imaging diagnosis of cancers[J]. Nano Lett, 2023, 23(18): 8628-8636. DOI: 10.1021/acs.nanolett.3c02466. pmid: 37694968
[8]	Carniato F, Ricci M, Tei L, et al. Novel nanogels loaded with Mn(Ⅱ)chelates as effective and biologically stable MRI probes[J]. Small, 2023, 19(42): 2302868. DOI: 10.1002/smll.202302868.
[9]	Liu Y, Bhattarai P, Dai Z, et al. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer[J]. Chem Soc Rev, 2019, 48(7): 2053-2108. DOI: 10.1039/c8cs00618k. pmid: 30259015
[10]	Yu Y, Feng T, Qiu H, et al. Simultaneous photoacoustic and ultrasound imaging: a review[J]. Ultrasonics, 2024, 139: 107277. DOI: 10.1016/j.ultras.2024.107277.
[11]	Neuschler EI, Butler R, Young CA, et al. A pivotal study of optoacoustic imaging to diagnose benign and malignant breast masses: a new evaluation tool for radiologists[J]. Radiology, 2018, 287(2): 398-412. DOI: 10.1148/radiol.2017172228. pmid: 29178816
[12]	Teng L, Han X, Liu Y, et al. Smart nanozyme platform with activity-correlated ratiometric molecular imaging for predicting therapeutic effects[J]. Angew Chem Int Ed Engl, 2021, 133(50): 26346-26354. DOI: 10.1002/anie.202110427.
[13]	Tang Q, Cheng Z, Yang N, et al. Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy[J]. Biomaterials, 2019, 205: 1-10. DOI: 10.1016/j.biomaterials.2019.03.005. pmid: 30889497
[14]	Lv Y, Kan J, Luo M, et al. Multifunctional nanosnowflakes for T1-T2 double-contrast enhanced MRI and PAI guided oxygen self-supplementing effective anti-tumor therapy[J]. Int J Nanomedicine, 2022, 17: 4619-4638. DOI: 10.2147/IJN.S379526.
[15]	Vogel A, Meyer T, Sapisochin G, et al. Hepatocellular carcinoma[J]. Lancet, 2022, 400(10360): 1345-1362. DOI: 10.1016/S0140-6736(22)01200-4. pmid: 36084663
[16]	Weber WA, Barthel H, Bengel F, et al. What is theranostics?[J]. J Nucl Med, 2023, 64(5): 669-670. DOI: 10.2967/jnumed.123.265670.
[17]	Pan YB, Xu CX, Deng HZ, et al. Localized NIR-Ⅱ laser mediated chemodynamic therapy of glioblastoma[J]. Nano Today, 2022, 43: 101435. DOI: 10.1016/j.nantod.2022.101435.
[18]	Zhang L, Yang Z, He W, et al. One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy[J]. J Colloid Interface Sci, 2021, 599: 543-555. DOI: 10.1016/j.jcis.2021.03.173.
[19]	Xu X, Zhang R, Yang X, et al. A honeycomb-like bismuth/manganese oxide nanoparticle with mutual reinforcement of internal and external response for triple-negative breast cancer targeted therapy[J]. Adv Healthc Mater, 2021, 10(18): 2100518. DOI: 10.1002/adhm.202100518.
[20]	Adams S, Gatti-Mays ME, Kalinsky K, et al. Current landscape of immunotherapy in breast cancer: a review[J]. JAMA Oncol, 2019, 5(8): 1205-1214. DOI: 10.1001/jamaoncol.2018.7147.
[21]	Lv MZ, Chen MX, Zhang R, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy[J]. Cell Res, 2020, 30(11): 966-979. DOI: 10.1038/s41422-020-00395-4.
[22]	Zhong H, Chen G, Li T, et al. Nanodrug augmenting antitumor immunity for enhanced TNBC therapy via pyroptosis and cGAS-STING activation[J]. Nano Lett, 2023, 23(11): 5083-5091. DOI: 10.1021/acs.nanolett.3c01008.
[23]	Rashid NS, Grible JM, Clevenger CV, et al. Breast cancer liver metastasis: current and future treatment approaches[J]. Clin Exp Metastasis, 2021, 38(3): 263-277. DOI: 10.1007/s10585-021-10080-4.
[24]	Zhong Y, Li T, Zhu Y, et al. Targeting proinflammatory molecules using multifunctional MnO nanoparticles to inhibit breast cancer recurrence and metastasis[J]. ACS Nano, 2022, 16(12): 20430-20444. DOI: 10.1021/acsnano.2c06713. pmid: 36382718
[25]	Wang SB, Zhang C, Ye JJ, et al. Near-infrared light responsive nanoreactor for simultaneous tumor photothermal therapy and carbon monoxide-mediated anti-inflammation[J]. ACS Cent Sci, 2020, 6(4): 555-565. DOI: 10.1021/acscentsci.9b01342.
[26]	Peng J, Dong M, Ran B, et al. "One-for-All"-type, biodegradable prussian blue/manganese dioxide hybrid nanocrystal for trimodal imaging-guided photothermal therapy and oxygen regulation of breast cancer[J]. ACS Appl Mater Interfaces, 2017, 9(16): 13875-13886. DOI: 10.1021/acsami.7b01365.
[27]	Xie W, Guo Z, Gao Q, et al. Manganese-doped layered double hydroxide: a biodegradable theranostic nanoplatform with tumor microenvironment response for magnetic resonance imaging-guided photothermal therapy[J]. ACS Appl Bio Mater, 2020, 3(9): 5845-5855. DOI: 10.1021/acsabm.0c00564. pmid: 35021812
[28]	Niu B, Liao K, Zhou Y, et al. Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy[J]. Biomaterials, 2021, 277: 121110. DOI: 10.1016/j.biomaterials.2021.121110.
[29]	Yuan P, Deng FA, Liu YB, et al. Mitochondria targeted O₂ economizer to alleviate tumor hypoxia for enhanced photodynamic therapy[J]. Adv Healthc Mater, 2021, 10(12): 2100198. DOI: 10.1002/adhm.202100198.
[30]	Zhou X, Xu X, Hu Q, et al. Novel manganese and polyester dendrimer-based theranostic nanoparticles for MRI and breast cancer therapy[J]. J Mater Chem B, 2023, 11(3): 648-656. DOI: 10.1039/d2tb01855a.
[31]	Li W, Li R, Ye Q, et al. Mn₃O₄ nanoshell coated metal-organic frameworks with microenvironment-driven O₂ production and GSH exhaustion ability for enhanced chemodynamic and photodynamic cancer therapies[J]. Adv Healthc Mater, 2023, 12(15): 2202280. DOI: 10.1002/adhm.202202280.
[32]	Beckers C, Pruschy M, Vetrugno I. Tumor hypoxia and radiotherapy: a major driver of resistance even for novel radiotherapy modalities[J]. Semin Cancer Biol, 2024, 98: 19-30. DOI: 10.1016/j.semcancer.2023.11.006. pmid: 38040401
[33]	He Z, Yan H, Zeng W, et al. Tumor microenvironment-responsive multifunctional nanoplatform based on MnFe₂O₄-PEG for enhanced magnetic resonance imaging-guided hypoxic cancer radiotherapy[J]. J Mater Chem B, 2021, 9(6): 1625-1637. DOI: 10.1039/d0tb02631j.
[34]	Hu H, Zheng S, He C, et al. Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction[J]. J Nanobiotechnology, 2024, 22(1): 234. DOI: 10.1186/s12951-024-02502-8.
[35]	Xiong Y, Xiao C, Li Z, et al. Engineering nanomedicine for glutathione depletion-augmented cancer therapy[J]. Chem Soc Rev, 2021, 50(10): 6013-6041. DOI: 10.1039/d0cs00718h. pmid: 34027953
[36]	Zhang H, Li M, Zhu X, et al. Artemisinin co-delivery system based on manganese oxide for precise diagnosis and treatment of breast cancer[J]. Nanotechnology, 2021, 32(32): 325101. DOI: 10.1088/1361-6528/abfc6f.
[37]	Jain P, Patel K, Jangid AK, et al. Biotinylated Mn₃O₄ nanocuboids for targeted delivery of gemcitabine hydrochloride to breast cancer and MRI applications[J]. Int J Pharm, 2021, 606: 120895. DOI: 10.1016/j.ijpharm.2021.120895.

编辑推荐 0

Metrics

阅读次数

全文

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	5	0	0	35

来源	本网站	其他网站

次数	21	19
比例	52%	48%

摘要

最新录用	在线预览	正式出版

0	0	38

来源	本网站	其他网站

次数	24	14
比例	63%	37%