复发难治性多发性骨髓瘤的免疫靶向治疗及存在的问题

doi:10.3760/cma.j.cn371439-20200622-00074

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (6): 381-384.doi: 10.3760/cma.j.cn371439-20200622-00074

• 综述 • 上一篇

复发难治性多发性骨髓瘤的免疫靶向治疗及存在的问题

孙睿婕¹, 单宁宁^1,²()

¹山东大学附属省立医院山东省立医院血液内科,济南 250021
²山东第一医科大学附属省立医院山东省立医院血液内科,济南 250021

收稿日期:2020-06-22 修回日期:2020-07-22 出版日期:2021-06-08 发布日期:2021-06-24
通讯作者: 单宁宁 E-mail:snning@126.com
基金资助:
济南市科技计划(201907021)

Immune, targeted therapy and related issues of relapsed/refractory multiple myeloma

Sun Ruijie¹, Shan Ningning^1,²()

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital, Jinan 250021, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital, Jinan 250021, China

Received:2020-06-22 Revised:2020-07-22 Online:2021-06-08 Published:2021-06-24
Contact: Shan Ningning E-mail:snning@126.com
Supported by:
Science and Technology Plan of Jinan of China(201907021)

摘要/Abstract

摘要：

多发性骨髓瘤以及复发难治性多发性骨髓瘤的新型免疫靶向治疗药物主要包括免疫调节剂、蛋白酶体抑制剂、单克隆抗体、免疫检查点抑制剂、组蛋白去乙酰化酶及嵌合抗原受体。尽管自体造血干细胞移植及新药的应用改善了患者预后,但仍需更有效的治疗手段和策略应对治疗中出现的不良反应及复发情况。

关键词: 多发性骨髓瘤, 分子靶向治疗, 免疫治疗

Abstract:

The new immune and targeted therapy medicines of multiple myeloma and recurrence of refractory multiple myeloma mainly include immunomodulatory drugs, proteasome inhibitors, monoclonal antibody, immune monitoring point inhibitors, histone deacetylase and chimeric antigen receptor. Although the emergence of new drugs and the application of autologous hematopoietic stem cell transplantation have significantly improved the prognosis of patients, more effective treatment methods and treatment strategies are still required to deal with the adverse reactions and the condition of recurrence during treatment.

Key words: Multiple myeloma, Molecular targeted therapy, Immunotherapy

孙睿婕, 单宁宁. 复发难治性多发性骨髓瘤的免疫靶向治疗及存在的问题[J]. 国际肿瘤学杂志, 2021, 48(6): 381-384.

Sun Ruijie, Shan Ningning. Immune, targeted therapy and related issues of relapsed/refractory multiple myeloma[J]. Journal of International Oncology, 2021, 48(6): 381-384.

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复发难治性多发性骨髓瘤的免疫靶向治疗及存在的问题

Immune, targeted therapy and related issues of relapsed/refractory multiple myeloma

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