卡波西肉瘤相关疱疹病毒与宿主免疫在卡波西肉瘤发病中的作用机制及免疫治疗

doi:10.3760/cma.j.cn371439-20200923-00073

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (6): 377-380.doi: 10.3760/cma.j.cn371439-20200923-00073

卡波西肉瘤相关疱疹病毒与宿主免疫在卡波西肉瘤发病中的作用机制及免疫治疗

王芳, 王鹏, 康晓静()

新疆维吾尔自治区人民医院皮肤性病科新疆皮肤病研究重点实验室,乌鲁木齐 830001

收稿日期:2020-09-23 修回日期:2020-10-16 出版日期:2021-06-08 发布日期:2021-06-24
通讯作者: 康晓静 E-mail:drkangxj666@163.com
基金资助:
新疆维吾尔自治区创新环境(人才、基地)建设专项“天山创新团队计划”(2020D14006)

Mechanism and immunotherapy of Kaposi sarcoma-associated herpesvirus and host immunity in the pathogenesis of Kaposi sarcoma

Wang Fang, Wang Peng, Kang Xiaojing()

Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, China

Received:2020-09-23 Revised:2020-10-16 Online:2021-06-08 Published:2021-06-24
Contact: Kang Xiaojing E-mail:drkangxj666@163.com
Supported by:
Xinjiang Uygur Autonomous Region Innovation Environmen (Talent,Base) Construction Project “Tianshan Innovation Team Plan” of China(2020D14006)

摘要/Abstract

摘要：

卡波西肉瘤是一种软组织多发性色素性血管瘤,其病因尚不明确,其发生发展与卡波西肉瘤相关疱疹病毒相关。卡波西肉瘤相关疱疹病毒可通过干扰模式识别受体、补体系统或直接作用于免疫细胞逃避宿主免疫系统,从而在卡波西肉瘤的发生与发展中起重要作用,免疫调节剂、靶向药物及疫苗等免疫治疗有望成为预防及治疗卡波西肉瘤的新方法。

关键词: 肉瘤, 卡波西, 卡波西肉瘤相关疱疹病毒, 宿主免疫, 免疫治疗

Abstract:

Kaposi sarcoma is a multiple pigmented hemangioma of soft tissue. The etiology of Kaposi sarcoma is still unclear. Its occurrence is related to Kaposi sarcoma-related herpesvirus. Kaposi sarcoma-associated herpes virus plays an important role in the occurrence and development of Kaposi sarcoma by interfering with the pattern recognition receptors, complement system, or effecting on the immune cells directly to evasive host immune system. The immune modulators, immunotherapy of targeted drugs and vaccines are expected to be the new methods for the prevention and treatment of Kaposi sarcoma.

Key words: Sarcoma, Kaposi, Kaposi sarcoma-associated herpesvirus, Host immune, Immunotherapy

王芳, 王鹏, 康晓静. 卡波西肉瘤相关疱疹病毒与宿主免疫在卡波西肉瘤发病中的作用机制及免疫治疗[J]. 国际肿瘤学杂志, 2021, 48(6): 377-380.

Wang Fang, Wang Peng, Kang Xiaojing. Mechanism and immunotherapy of Kaposi sarcoma-associated herpesvirus and host immunity in the pathogenesis of Kaposi sarcoma[J]. Journal of International Oncology, 2021, 48(6): 377-380.

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卡波西肉瘤相关疱疹病毒与宿主免疫在卡波西肉瘤发病中的作用机制及免疫治疗

Mechanism and immunotherapy of Kaposi sarcoma-associated herpesvirus and host immunity in the pathogenesis of Kaposi sarcoma

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