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08 August 2017, Volume 44 Issue 8 Previous Issue    Next Issue

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Effect of ionizing radiation on the NKG2D ligand expression on the tumor cell SCC25 surface and the killing effect on tumor cells Miao Nana, Tu Wenyong, Kong Yuehong, Wang Xu, Xu Xuanli 2017, 44 (8):  561-564.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.001 Abstract ( 355 )   PDF (1099KB) ( 939 )   Save Objective To investigate the effect of ionizing radiation on the expression of NKG2D ligand on the surface of oral squamous cell carcinoma cell line SCC25 and its cytotoxicity to tumor cells. Methods When SCC25 cells were cultured into logarithmic growth phase, they were randomly designed as control (without treatment) and experimental group (2 Gy ionizing radiation treatment) by drawing lots. Flow cytometry was used to detect the expressions of NKG2D ligands major histocompatibility complex class Ⅰ chainrelated molecule (MIC)A, MICB, UL16 binding protein (ULBP)1 on the surface of SCC25 in the control group and the experimental group cultured for 24 h. Real-time fluorescence quantification polymerase chain reaction (RT-PCR) was used to detect the changes of NKG2D ligand mRNA expression on SCC25 cell surface after 24 h culture in the experimental group and the control group. The cells were prepared and divided into blank control group (NC), 2 Gy ionizing radiation group (R), NK1 group (target ratio was 5∶1), NK2 group (target ratio was 20∶1), NK1+R group (target ratio was 5∶1, 2 Gy ionizing radiation), NK2+R group (target ratio was 20∶1, 2 Gy ionizing radiation). After each group was cultured for 24 h, the killing abilities of ionizing radiation and natural killer (NK) cells to oral squamous cell carcinoma SCC25 cells were detected by CCK8. Results Flow cytometry experiment showed that, among the NKG2D ligands, the MICA fluorescence values of experimental group and control group were respectively 21.04±0.39, 22.90±0.40 (t=2.465, P=0.069), MICB fluorescence values were 27.58±0.50, 29.83±1.05 (t=1.936, P=0.125), and ULBP1 fluorescence values were 21.04±0.40, 21.78±0.50 (t=1.154, P=0.313). This indicated that after ionizing radiation on SCC25, the NKG2D ligand MICA, MICB, ULBP1 expression increased slightly, but the differences were not statistically significant. RT-PCR indicated that mRNA expressions of MICB, ULBP1 were significantly different between the control group and the experimental group (t=18.334, P=0.000; t=6.381, P=0.008). The expressions of the experimental group were respectively 6.49, 1.64 times as those of the control group. The results of CCK8 showed that, there was a significant difference in cell killing ability among NK1 group, NK2 group and NC group (F=344.600, P=0.000), suggesting that NK cells could kill tumor cells, and the higher ratio of NK cells and SCC25, the stronger killing effect. The comparison between R group and NC group showed that the difference in cell killing ability was not statistically significant (P=0.567). NK1+R group and NK1 group were compared and the difference was not statistically significant (P=0.915). There was no significant difference between NK2+R group and NK2 group (P=0.678). This showed that the killing effect of ionizing radiation was weak. Conclusion  Ionizing radiation can increase the mRNA expression of NKG2D ligands MICB and ULBP1. This may provide a new way for tumor immunotherapy. The killing effect of ionizing radiation on cells is not obvious. It may be related to low radiation dose and only 24 h for cell culture. Related Articles | Metrics

Expression and clinical significance of OTUB1 in breast cancer Duan Fei, Zhang Jinyu, Liu Jing, Ma Zhenfeng, Cui Naipeng, Liu Xianyi, Chen Baoping 2017, 44 (8):  565-568.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.002 Abstract ( 486 )   PDF (1141KB) ( 922 )   Save Objective  To explore the expression level of OTUB1 and its clinical significance in breast cancer. Methods  Immunohistochemistry was used to detect the expression level of OTUB1 in 78 cases of breast cancer tissues and 30 cases of normal breast tissue adjacent to carcinoma, and the relationships between OTUB1 and the clinical pathological features of breast cancer were analyzed. Results  The positive expression rate of OTUB1 in breast cancer tissues ［66.7% (52/78)］ was significantly higher than that in adjacent normal breast tissues ［30.0% (9/30)］, with a statistically significant difference (χ2=11.851, P=0.001). OTUB1 expression level was related to the lymph node metastasis (χ2=5.029, P=0.025), postoperative TNM staging (χ2=4.478, P=0.034), expression of human epidermal growth factor receptor2 (HER2) (χ2＝8.775,P=0.003), expression of P53 (χ2=4.708, P=0.030), expression of estrogen receptor (ER) (χ2=10.364,P=0.001) and molecular subtypes (χ2＝10.934, P=0.012). However, OTUB1 expression level in breast cancer was not related to the age (χ2=2.194, P=0.139), menopausal status (χ2=1.843, P=0.175), tumor size (χ2=0.643, P=0.423), histological grade (χ2=3.580, P=0.167), expression of progestin receptor (PR) (χ2=3.371, P=0.066) and expression of Ki67 (χ2=1.345, P=0.246). Conclusion  OTUB1 expression level increases in breast cancer, which is associated with the lymph node metastasis, TNM staging, expressions of HER-2, P53, ER and molecular subtypes of breast cancer. It suggests that the expression of OTUB1 is related to the progression and metastasis of breast cancer. Related Articles | Metrics

Changes of serum levels of VEGF, Arg-1 and iNOS in NSCLC patients before and after microwave ablation and their correlations Nie Xuerong, Dong Liangliang, Zhang Liangming 2017, 44 (8):  569-572.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.003 Abstract ( 445 )   PDF (869KB) ( 937 )   Save Objective  To investigate the curative effect of microwave ablation for non-small cell lung cancer (NSCLC) patients, and to analyze the serum concentration changes of vascular endothelial growth factor (VEGF), arginase-1 (Arg-1), inducible nitric oxide synthase (iNOS) before and after microwave ablation and their correlations. Methods  A total of 30 cases of healthy people (control group) and 30 cases of advanced NSCLC (test group) were selected. The serum concentrations of VEGF, Arg-1 and iNOS in control group and test group (before microwave ablation, the first postoperative day, the third postoperative day and the first postoperative month) were measured by enzymelinked immunosorbent assay (ELISA). Results  The effective rate of microwave ablation for advanced NSCLC was 33.3% （10/30）, and the disease control rate was 70.0% （21/30）. The concentrations of VEGF, Arg-1 and iNOS in test group before microwave ablation were (816.56±13.26)pg/ml, (5.17±0.20)ng/ml and (544.18±13.93)pg/ml, which were higher than those in control group (93.43±9.93)pg/ml, (1.08±0.05)ng/ml and (8.08±0.33)pg/ml, and the differences were statistically significant (t=239.093, P＜0.001; t=110.359, P＜0.001;t=210.792, P＜0.001). The concentrations of VEGF were (708.41±10.49)pg/ml, (592.63±7.25)pg/ml and (521.91±8.32) pg/ml on the first day, third day and 1 month after microwave ablation in patients with advanced NSCLC, which were significantly lower than those before treatment (all P＜0.05). The homologous concentrations of Arg-1 were (5.95±0.10)ng/ml, (7.02±0.13)ng/ml and (7.67±0.92)ng/ml, which were significantly higher than those before treatment (all P＜0.05). The homologous concentrations of iNOS were (453.01±9.48)pg/ml, (393.21±9.42)pg/ml and (352.60±8.31)pg/ml, which were significantly lower than those before treatment (all P＜0.05). The expression of iNOS was positively related with VEGF in NSCLC patients before treatment (r=0.379,P=0.039), and the expression of Arg1 was negatively related with VEGF (r=-0.556, P=0.001). However, the expression of iNOS was not associated with Arg1 (r=-0.238, P=0.205). Conclusion  Microwave ablation is effective for local therapy of NSCLC, which can directly kill cancer cells, and affect the levels of VEGF, Arg-1 and iNOS. VEGF has certain correlation with iNOS and Arg-1, but there was no correlation between iNOS and Arg-1. Microwave ablation can change the tumor microenvironment in a certain extent, and stimulate the body to produce anti-tumor immunity. Related Articles | Metrics

Value of multislice spiral CT in differential diagnosis of pure groundglass nodule of 1 cm or less in lung infiltrating adenocarcinoma and before infiltration Nan Jing 2017, 44 (8):  573-577.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.004 Abstract ( 700 )   PDF (1231KB) ( 1419 )   Save Objective  To analyze CT imaging features of lung pure ground-glass nodule (pGGN) of 1 cm or less, and to discuss the differential diagnosis value of multi-slice spiral CT (MSCT) of lung pGGN of 1 cm or less in lung infiltrating adenocarcinoma and before infiltration. Methods  A total of 103 patients with lung pGGN≤1 cm admitted to the First Hospital of Handan from January 2012 to August 2016 were selected. Of the 103 lung pGGN lesions, there were 67 preinvasive lesions (the preinvasive lesion group) confirmed by operation, including 28 atypical adenomatous hyperplasia and 39 adenocarcinoma in situ. There were 36 invasive lesions (the infiltration group), including 21 minimally invasive adenocarcinoma and 15 invasive adenocarcinoma. All the patients underwent MSCT scanning, and the lesion location, size, CT value, internal density, edge, peripheral vessel and lungtumor interface were compared between the two pathological types. The receiver operating characteristic curves of the size of the infiltrating lesion and before infiltration were drawn, and the boundary values of the size of the two kinds of pGGN were analyzed and identified. Results  The differences of the lesion location (χ2＝0.529,P=0.746), vacuole sign (χ2＝1.581, P=0.209), aerated bronchus sign (χ2=1.639, P=0.201), edge of the lesion (χ2=0.614, P=0.722) between the two groups were not statistically significant. The proportion of clear lungtumor interface in infiltration group was higher than that in preinvasive lesion group (86.11% vs. 44.78%; χ2=16.568,P＜0.001). The proportion of type Ⅰ in the classification of pulmonary vascular relationships in infiltration group was lower than that in preinvasive lesion group (5.56% vs. 41.79%; χ2=14.894,P＜0.001), and the proportion of type Ⅲ in infiltration group was higher than that in preinvasive lesion group (38.89% vs.1.49%; χ2=26.320, P＜0.001). The average maximum diameter of the infiltration group ［(0.85±0.17)cm］ was greater than that of the preinvasive lesion group ［(0.76±0.16)cm］, and the difference was statiscally significant (t=2.663, P=0.009). The boundary value to identify the size of the preinvasive and invasive lesions was 0.81 cm, and its sensitivity and specificity rates were 62.1% and 63.5%, and the area under the curve was 0.622. Conclusion  Of lung pGGN≤1 cm, invasive lesions are larger, lungtumor interface is more clear, and the proportion of type Ⅲ in the classification of pulmonary vascular relationships is bigger. MSCT can present the above imaging characteristics of lesions, and it has the important value in differential diagnosis of lung pGGN≤1 cm in infiltrating adenocarcinoma and before infiltration. Related Articles | Metrics

Clinical observation of intrapleural hyperthermic perfusion chemotherapy for patients with malignant pleural effusion caused by lung cancer Zhang Junqing, Wang Juncheng, Zhang Gaiying, Chen Jing, Wu Tieying 2017, 44 (8):  578-582.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.005 Abstract ( 529 )   PDF (1827KB) ( 1155 )   Save Objective  To observe the efficacy and adverse reaction of intrapleural hyperthermic perfusion and intrapleural chemotherapy for patients with malignant pleural effusion (MPE) caused by lung cancer. Methods  A total of 103 patients with MPE caused by lung cancer were assigned into one of two groups: intrapleural hyperthermic perfusion group (n=65) and intrapleural chemotherapy group (n=38). The disease control rate, MPE progress free survival, the relationship between vascular endothelial growth factor (VEGF) concentration in pleural effusion and curative effect and adverse reactions were observed.Results  The overall disease control rate in intrapleural hyperthermic perfusion group and intrapleural chemotherapy group was 81.5% and 52.6% respectively, with a significant difference (χ2=9.834, P=0.002). The median MPE progress free survival of the two groups was 3.10 and 2.15 months respectively, with a significant difference (χ2=10.512,P=0.001). A significant difference of the median MPE progress free survival was observed in low VEGF concentration subgroup between intrapleural hyperthermic perfusion and intrapleural chemotherapy (3.34 months vs. 2.20 months; χ2=9.409, P=0.002), but no difference was observed in high VEGF expression subgroup (2.85 months vs. 2.10 months; χ2=2.429, P=0.119). The main adverse reactions included gastrointestinal adverse reaction, fatigue and hematotoxicity. Fatigue occurred in intrapleural hyperthermic perfusion group more commonly compared with intrapleural chemotherapy group (67.7% vs. 13.2%; χ2=28.595, P＜0.001). Conclusion  Compared with intrapleural chemotherapy, intrapleural hyperthermic perfusion can better improve disease control rate and MPE progress free survival in MPE patients caused by lung cancer, and it′s adverse reactions are tolerated easily. The MPE progress free survival prolonging is observed especially in VEGF low expression subgroup. VEGF level in pleural effusions maybe could predict efficacy of intrapleural hyperthermic perfusion. Related Articles | Metrics

Clinical observation of raltitrexed containing regimen for advanced colorectal cancer Chen Ling, Guo Zengqing, Wang Xiaojie, Chen Yu, Yu Jiam 2017, 44 (8):  583-586.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.006 Abstract ( 448 )   PDF (936KB) ( 887 )   Save Objective  To observe the clinical efficacy and adverse reactions of raltitrexed containing regimen for advanced colorectal cancer as the second-line and multi-line treatment. Methods  A total of 42 patients with advanced colorectal cancer were treated with raltitrexed containing regimen. The objective response rate (ORR), disease control rate (DCR), median progressionfree survival (mPFS) and adverse reactions were evaluated. Results  The ORR of the 42 patients was 16.67%, DCR was 80.96%, and mPFS was 4.90 months (95%CI: 2.996.81 months). The most of adverse reactions were gradeⅠ-Ⅱ, including leucopenia (30.95%), thrombocytopenia (2.38%), anemia (40.48%), nausea and vomiting (2.38%), anorexia (4.76%), diarrhea (2.38%), transaminase elevation (47.62%) and fatigue (11.90%). Grade Ⅲ-Ⅳ transaminase elevation was found in only 4.76% of patients. Conclusion  Raltitrexed containing regimen for advanced colorectal cancer as the second-line and multi-line treatment is effective and well tolerated, and further clinical application is recommended. Related Articles | Metrics

Ribosomal proteins and tumors Ruan Xingya, Yang Mingxia 2017, 44 (8):  587-589.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.007 Abstract ( 693 )   PDF (816KB) ( 1709 )   Save The ribosome composed of ribosomal RNA and ribosomal proteins is well documented to be an important organelle for protein synthesis. Ribosomal proteins play crucial roles in protein translation. The dysregulation of ribosomal proteins and ribosomal RNA expression activates ribosomal proteins′ extraribosomal functions which is believed to play important roles in the tumorigenesis. It is possible that ribosomal proteins may serve as biomarkers or promising targets for the early diagonosis and therapy of tumor diseases. Related Articles | Metrics

Research status of endoplasmic reticulumautophagy pathway in drug resistance of tumor Sun Wanghong, Wang Haifeng, Yang Delin 2017, 44 (8):  590-593.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.008 Abstract ( 427 )   PDF (867KB) ( 1064 )   Save Autophagy plays a dual role in tumor therapy. A variety of chemotherapy drugs can induce tumor autophagy by activating endoplasmic reticulum stress, and hyperactive autophagy can cause tumor cell apoptosis and plays an antitumor effect. Autophagy has a protective effect on tumor cells, which can maintain the survival of tumor cells and reduce the sensitivity of chemotherapy drugs by reusing the degradation of the damaged organelles. Therefore, the promotion or inhibition of autophagy modulators combined with chemotherapy drugs will have the potential for development in tumor therapy. Related Articles | Metrics

Mechanism of tumor tolerance mediated by immune microenvironment and its targeted therapy Xu Yuanyuan, Zhang Li, Jin Liangkun 2017, 44 (8):  594-596.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.009 Abstract ( 564 )   PDF (800KB) ( 1698 )   Save Immune cells interact with their secreted cytokines forming immune microenvironment that plays an important role in the treatment resistance. Immune microenvironment induces tumor tolerance by reducing the antiapoptotic pathway, mediating immune tolerance, inducing epithelial mesenchymal transformation and the formation of tumor stem cells, reducing the curative effect. Tumor immunotherapy has become a hot topic in the field of tumor therapy research. Related Articles | Metrics

Clinical application of tumor heterogeneity based on MRI texture analysis Tao Hengmin, Wei Yumei, Qian Ming 2017, 44 (8):  597-600.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.010 Abstract ( 551 )   PDF (867KB) ( 1302 )   Save Heterogeneity is one of the important features of malignant tumors. MRI texture analysis (MTA) is a new imaging postprocessing technique to quantify heterogeneity of tumor. Increasing number of studies have shown that MTA is a potentially useful tool in tumor imaging, and can provide important and valuable information including tumor characteristics, prognosis assessment, prediction or monitoring of tumor treatment response, and so on. In this article, we review the literatures about MTA in evaluating heterogeneity of tumor. The correlation between MTA and tumor response to chemotherapy, prognosis and survival time, and the role of MTA as imaging markers in clinical practice are summarized, to further explore its potential in clinical application. Related Articles | Metrics

Expressions and roles of SOX families in glioma Li Yuanyuan, Zhu Shuxia 2017, 44 (8):  601-603.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.011 Abstract ( 727 )   PDF (801KB) ( 1095 )   Save Glioma is a common malignant tumor of nervous system. Many genes of SOX family are closely related to the genesis and development of glioma, among which SOX2, SOX4, SOX7, SOX9 gene are all abnormal in glioma. SOX2 gene is highly expressed in glioma and has positive correlation with the malignant grade of glioma. SOX2 gene coordinates with many factors and promotes the genesis and development of glioma. SOX4 gene plays as both a oncogene and a tumor suppressor gene in brain glioma, and can regulate a variety of factors. SOX7, as a tumor suppressor gene, shows low expression in glioma, and suppresses the genesis of brain glioma by regulating the related factors and signaling pathways. SOX9 gene is highly expressed in glioma tissues, and promotes tumorigenesis and metastasis of glioma by coordinating with a variety of factors, and can be used as an important risk factor for the prognosis of glioma patients. Related Articles | Metrics

Analysis of intratumor heterogeneity in breast cancer precision medicine Yi Zongbi, Ma Fei 2017, 44 (8):  604-607.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.012 Abstract ( 478 )   PDF (861KB) ( 1151 )   Save As a breakthrough of precision medicine, intratumor heterogeneity is a research hotspot and is correlated to tumorigenesis, metastasis and resistance to therapies. In breast cancer, evidence of intratumor heterogeneity has been documented by numerous studies and it is the main obstacle to find ideal tumor markers and personalized medicine. Further analysis including the feature and generation mechanism of intratumor heterogeneity and the methods to assessment intratumor heterogeneity in the clinic are the key to cancer precision medicine. Related Articles | Metrics

Alternative mode of whole-breast radiotherapy after breast-conserving surgery in early-stage breast cancer Zhang Qun, Li Duojie 2017, 44 (8):  608-611.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.013 Abstract ( 344 )   PDF (869KB) ( 1143 )   Save Wholebreast irradiation has been used to reduce the risk of ipsilateral breast tumor recurrence after breastconserving surgery for early breast cancer. A number of randomized clinical trials and metaanalyses have demonstrated the effectiveness and safety of wholebreast irradiation. With the progress of radiotherapy and the survival extented of patients, this standard treatment model is facing some challenges for different breast cancer groups, and its alternative model has been paid  more attention at the same time. The efficacy of partial breast irradiation, hypofactionated whole breast irradiation and the omission of breast RT are equivalent to wholebreast irradiation, while the side effects are reduced. In the same time, they shorten the treatment time of patient and reduce the burden on the patient, which is worth for popularization and application in clinic. Related Articles | Metrics

Holistic therapy of advanced non-small cell lung Zhang Baihong, Yue Hongyun 2017, 44 (8):  612-614.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.014 Abstract ( 343 )   PDF (800KB) ( 859 )   Save Holistic therapy of cancer is helping to design more effective cancer therapies by combination individual properties (such as performance status, histological types and molecular types) and novel clinical results. Holistic therapy in oncology reflects individual, precision, whole course and realtime treatment strategy, and includes sequential, synchronizational, interval and metronomic therapy models. Holistic therapy in oncology would be help in selecting appropriate choices for patients and clinic doctors. Related Articles | Metrics

MicroRNAs and ovarian cancer Hua Dingchao, Wang Xinyu 2017, 44 (8):  615-618.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.015 Abstract ( 352 )   PDF (867KB) ( 766 )   Save The abnormal expressions of microRNAs (miRNAs) are closely related to the genesis and development of ovarian cancer. MiRNAs are involved in carcinogenesis and progression, invasion and metastasis as well as drug resistance. As a kind of significant biomarker, miRNAs are expected to be novel targets for the early diagnosis and prognostic evaluation of ovarian cancer, which provide new ways for the therapy of ovarian cancer. Related Articles | Metrics

Association between MTHFR polymorphisms and colorectal cancer Zhang Huibo, Yang yanying, Song Qibin 2017, 44 (8):  619-621.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.016 Abstract ( 418 )   PDF (798KB) ( 879 )   Save Colorectal cancer (CRC) is one of the most common malignancies in the world. Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism process. In recent years, many studies indicate that MTHFR polymorphisms are significantly associated with the morbidity, response to chemotherapy and prognosis of CRC, but conclusions are inconsistent and remain to be further confirmed. Related Articles | Metrics

Applacation of imaging examination in the preoperative staging diagnosis of colorectal cancer Lu Rongzeng, Liu Jianshan, Lei Xing, Gao Yongtao, Gao Hongyan, Bai Tiecheng 2017, 44 (8):  622-625.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.017 Abstract ( 487 )   PDF (872KB) ( 854 )   Save The accuracy of preoperative staging diagnosis of colorectal cancer directly determines the accuracy of treatment and prognosis. Endoscopic ultrasonography, CT, MRI and positron emission tomography/computed tomography (PET/CT) imaging have their own advantages and disadvantages in preoperative staging of colorectal cancer. According to the actual situation of patients, choosing the best method of examination, when necessary, several effective methods combined, can improve the accuracy of preoperative staging diagnosis of colorectal cancer. Related Articles | Metrics

Advances of ecotropic viral integration site 1 gene in acute lymphoblastic leukemia Lu Jiao, Liu Dandan 2017, 44 (8):  626-628.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.018 Abstract ( 457 )   PDF (801KB) ( 839 )   Save As an proto-oncogene, ecotropic viral integration site 1 (EVI1) gene is overexpressed in acute myeloid leukemia (AML) because of chromosomal translocation or other genetic abnormalities, finally cause poor prognosis. In recent years, an increasing research of the expression of EVI1 in acute lymphoblastic leukemia (ALL), especially in pediatric ALL. The overexpression of EVI1 gene also suggest a poor prognosis, which is closely relate to the age. But the relationship between the expression of EVI1 gene and mixed lineage leukemia (MLL) and BCRABL gene rearrangement needs to be further studied. Researching the expression of EVI1 gene in ALL and exploring targeted therapeutic agents are important research directions in the future. Related Articles | Metrics

Relationship between microRNAs and diffuse large B-cell lymphoma and its effect Wang Xinchen, Ding Kaiyang 2017, 44 (8):  629-632.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.019 Abstract ( 441 )   PDF (868KB) ( 788 )   Save Diffuse large B-cell lymphoma (DLBCL) is the most common nonHodgkin lymphoma with a high degree of heterogeneity. Studies have  shown that microRNAs (miRNAs) are involved in many biological processes and are closely related to lymphoid hematopoietic system and play an important role in various stages of B-cell differentiation and malignant transformation. miRNAs are increasingly concerned as a potential biomarker, which are closely related to the classification of DLBCL. miRNAs are of great values for the diagnosis of the disease and help to determine the prognosis of different patients, which may become new therapeutic targets. Related Articles | Metrics

Immunotherapy for lymphoma Wang Jiangtao, Guan Tao, Su Liping 2017, 44 (8):  633-637.  doi: 10.3760/cma.j.issn.1673-422X.2017.08.020 Abstract ( 758 )   PDF (935KB) ( 1025 )   Save At present, immunotherapies for lymphoma are becoming gradually important. Chimeric antigen receptormodified T cells therapy, bispecific antibody and immunecheckpoint inhibitor are considered as breakthrough treatments, each has its own unique mechanism, and more advanced treatments will be developed based on them. Related Articles | Metrics