Abstract: ObjectiveTo explore the correlation of peritumoral brain edema (PTBE) size, histological grades and the expression rate of Ki67 in gliomas. MethodsThe data and specimens about 74 cases of gliomas in People's Hospital of Xinjiang Uygur Autonomous Region during 20102013 were collected. All cases were confirmed by surgery and pathology. According to preoperative MRI, PTBE was graded. Immunohistochemical discriminate the expression of Ki67. HE coloration distinguish the histological grades.ResultsIn this study, 90.54% (67/74) patients occured PTBE, the incidence of PTBE inⅠ, Ⅱ, Ⅲ, Ⅳ level of groups were 100%(3/3), 78.95% (15/19), 83.33% (15/18), 100% (34/34). Ki67 expression was positive in 75.68% (56/74) patients, and the rates were 0, 36.84% (7/19), 94.44% (17/18), 94.12% (32/34) in Ⅰ, Ⅱ, Ⅲ, Ⅳ level of groups. The expression rate of Ki67 was 57.14% (4/7), 60.00% (6/10), and 80.70% (46/57) in  normal group, Ⅰlevel groups of PTBE, Ⅱlevel groups of PTBE. The result of KruskalWallis H showed that  the PTBE from different grades was statistically significant (H=11.304, P=0.010). The expression rate of Ki67 in different grade gliomas was statistically significant (H=38.530, P＜0.05), The difference of expression Ki67 in gliomas of different PTBE was statistically significant (H=6.478, P=0.039). The result of Spearman rank correlation analysis showed that the PTBE level increased with the histological grade up in gliomas (r=0.385, P=0.001). The expression rate of Ki67 increased with the histological grade up in gliomas (r=0.692, P＜0.05), and the expression rate of Ki67 increased with the degree of  PTBE up in glomas (r=0.256, P=0.028).ConclusionAccorrding to the PTBE size, the histological grades and proliferation ability of glioma can be judged preoperation. Ki67 can be used as the indicator of proliferation activity of tumor, and also be used as the important basis of histological grades.

Key words: Glioma, Peritumoral edema, Pathological grade, Ki67 antigen