Abstract: Bone tumor is one kind of malignant tumor which threats life among children and adolescent. Osteosarcoma(OS) and Ewing sarcoma(ES) have been paid much attention by medical community because of their complex occurrence, development, metastasis mechanism and poor prognosis. The research showed that activation of protooncogene and mutation of suppressor gene, absence of apoptosis signal and hypoxiainducible factor (HIF) all participated in the occurrence, development and metastasis of OS and ES. It is suggested that clarified pathomechanism of bone tumors could provide more effective therapeutic strategies and lower the mortality of patients.

Key words: Bone neoplasms, Osteosarcoma, Ewing sarcoma, Neoplasm metastasis