Journal of International Oncology ›› 2014, Vol. 41 ›› Issue (6): 405-407.

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Effect of miRNA on radiosensitivity and chemosensitivity in glioma stem cells

 CHEN  Jia-Rong, SUN  Quan-Quan, ZHANG  Tian, LU  Yan-Meng, YUAN  Ya-Wei   

  1. *Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Yuan Yawei E-mail:yuanyw66@aliyun.com

Abstract: The expression of microRNA (miRNA) is closely related to radiochemosensitivity in glioma stem cells (GSCs). Moreover, the growth of glioma stem cells could be inhibited comprehensively by increasing radiochemosensitivity and apoptosis, simultaneously with the regulation of a single miRNA, which has been confirmed by some researches. Thereby microRNA is prospective for the adoption  as a specific agent in targeted therapy of glioma, so as to increase the radiochemosensitivity in glioma stem cells.

Key words: MicroRNAs, Glioma, Neoplastic stem cells, Radiotherapy, Drug therapy