Abstract: Ceramide (Cer), as the center molecular of sphingolipids metabolism, functions as a bioactive mediator of different cellular processes, such as cell growth, differentiation, senescence and apoptosis, besides being structural component of cellular membrane. It can inhibit cell proliferation and promote cell apoptosis via multiple signal pathawys. Chemicals anticancer properties based on Cer metabolism that upregulate its level are confirmed in plenty of experimental researches, and parts of research productions are applied in anticancer clinic experiments.

Key words: font-family: 'Calibri','sans-serif', mso-bidi-font-size: 11.0pt, mso-ascii-theme-font: minor-latin, mso-fareast-theme-font: minor-fareast, mso-hansi-theme-font: minor-latin, mso-bidi-font-family: 'Times New Roman', mso-bidi-theme-font: minor-bidi, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体">Ceramides, Apoptosis, Neoplasms, Therapy