Abstract: Nowadays, antiplatelet and anticoagulant drugs has been applied to a variety of cardiovascular diseases, such as atrial fibrillation and coronary artery disease. Several clinical studies show that there is a higher prevalence of gastrointestinal cancers in patients with cardiovascular disease. In addition, in patients taking antithrombotic drugs, positive fecal occult blood test (FOBT) improves the sensitivity for early detection of colorectal malignancies. This suggests that antithrombotic drugs may facilitate the detection of unrecognized cancers in patients with cardiovascular disease. However, there is no established evidence concerning whether more aggressive gastrointestinal tract screening will reduce the mortality of cancer in cardiology patients. But in an era of multiple antithrombotic drug usage, when patients appear unexplained anemia, gastrointestinal symptoms or positive FOBT, timely gastrointestinal tract screening is helpful to find concomitanted malignancies in these patients.

Key words: Gastrointestinal neoplasms, Cardiovascular dieases, Fibrinolytic agents, Endoscopy