Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (3): 187-190.

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Animal model of tumor invasion in cancer-related research

QIN  Lin, YUE  Wen-Tao, WANG  Zi-Tong   

  1. QIN Lin*, YUE Wen-tao, WANG Zi-tong. *Department of Thoracic Surgery, Affiliated Beijing Chest Hospital of Capital Medical University, Beijing 101149, China

  • Online:2013-03-08 Published:2013-02-25
  • Contact: WANG Zi-tong, E-mail: wztdoctor@163.com E-mail:wztdoctor@163.com

Abstract: Tumor invasion model is an important tool to study the mechanisms of tumor invasion and to evaluate prevention and treatment of cancer. Compared to the in vitro model, in vivo model can simulate the tumor microenvironment and tumor invasion biological behaviour better. Morphological observation and invasion-related protein detection can be used to evaluate the animal invasion model, which are widely used in basic and clinical research now.

Key words: Models, animal, Neoplasm invasiveness, Immunohistochemistry