Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (1): 3-5.

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LATS2 gene and tumor

ZHANG  Yan-Ru, YU  Zhen, QIU  Lu-Gui   

  1. Institute of Hematology, Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin300020, China
  • Online:2013-01-08 Published:2013-01-15
  • Contact: Corresponding author: YU zhen, E-mail: yuyuzhen2003@yahoo.com.cn E-mail:yuyuzhen2003@yahoo.com.cn

Abstract: LATS2 gene, as one homolog of LATS tumor suppressor family, plays an important role in the control of cell cycles and tumor development through Hippo pathway, p53 gene and Ras-ERK signal transduction. Once an aberrant expression of LATS2 in cell to happen, it may lead to the tumor occurrence.

Key words: Neoplasms, Signal transduction, Gene expression