Wnt signaling pathway antagonist SOX17 in cancer

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (10): 735-737.

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Wnt signaling pathway antagonist SOX17 in cancer

CUI Su-Fen, WANG Zhi-Zhi, ZHANG Ling-Ling

Department of Gynecology and Obstetrics, Yangzhou No.1 People′s Hospital, Yangzhou 225012, China

Online:2012-10-31 Published:2012-10-31
Contact: ZHANG Ling-ling, E-mail: fckzhang@163.com E-mail:fckzhang@163.com

Abstract

Abstract: SOX17, a member of the SOX family of transcription factors, is conserved in many species and plays an important role in the formation of embryo endoderm. A number of studies have found that SOX17 gene expression is silenced or decreased might be due to promoter hypermethylation, which plays a vital role in tumorigenesis and tumor progression, and may contribute to aberrant activation of canonical Wnt signaling pathway in several human malignant tumors.

Key words: Neoplasms, SOX17 protein, Wnt signaling pathway

CUI Su-Fen, WANG Zhi-Zhi, ZHANG Ling-Ling. Wnt signaling pathway antagonist SOX17 in cancer[J]. Journal of International Oncology, 2012, 39(10): 735-737.

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Wnt signaling pathway antagonist SOX17 in cancer

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