Abstract: P53 protein plays a crucial role in inhibition tumor development. It will accumulate in cells in the condition of DNA damage,oncogenes activation or stress. As a nuclear transcription factor，P53 can transactivate the genes which correlate with apoptosis, cell cycle control and other procedures. Current research reveals P53 outside the nucleus can induce apoptosis and inhibit autophagy which contributes to its function of tumor suppression. The study of the extranuclear function of P53 is beneficial to further understanding the mechanism of P53 in the genesis and  development of tumor.  

Key words: Tumor suppressor protein p53, Transcription, Mitochondria, Autophagy