Thyroid hormone and tumor angiogenesis

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (8): 573-575.

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Thyroid hormone and tumor angiogenesis

HU Yang-Zhi, PAN Yun-Long, ZHAO Xiao-Xu, QIN Li, DING Hui

*Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China

Online:2012-08-29 Published:2012-08-29
Contact: PAN Yun-long, E-mail: tpanyl@jnu.edu.cn E-mail:tpanyl@jnu.edu.cn

Abstract

Abstract: Thyroid hormone is an important hormone for regulating cell differentiation, growth and metabolism. Many studies have shown that thyroid hormone can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at cell surface. Tetraiodothyroacetic acid is the analogue of thyroid hormone, and can inhibit tumor angiogenesis by inhibiting the binding of thyroid hormone with integrin ανβ3. Studying the role of thyroid hormone in promoting tumor angiogenesis may provide a new approach for molecular targeted therapy of tumor.

Key words: Thyroxine, Neoplasms, Targeted therapy

HU Yang-Zhi, PAN Yun-Long, ZHAO Xiao-Xu, QIN Li, DING Hui. Thyroid hormone and tumor angiogenesis[J]. Journal of International Oncology, 2012, 39(8): 573-575.

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Thyroid hormone and tumor angiogenesis

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