Abstract: Most anticancer drugs inhibit tumor cell growth by inducing apoptosis. Apoptosis-evasion, also enhancement of antiapoptosis ability (e.g. anti-apoptosis related genes over-expression or pro-apoptotic related genes loss, etc.) may lead to tumor cell multidrug resistance. Many researches show that apoptosis-evasion is one of the important factors resulting in tumor multidrug resistance.

Key words: Drug resistance,neoplasm, Apoptosis, Tumor escape