Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (5): 373-375.doi: 10.3760/cma.j.issn.1673422X.2017.05.012

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The mechanism of MLN4924 for anticancer therapy

Yang Mi, Cen Hongren, Long Cheng, Fu Jiejun   

  1. Translational Medicine Research Center of Guangxi Medical University, Nanning 530021, China
  • Online:2017-05-08 Published:2017-04-19
  • Contact: Fu Jiejun E-mail:fujiejun@126.com
  • Supported by:

     National Natural Fundation of China (81201669, 81560483)

Abstract: MLN4924 can inhibit the proliferation, invasion and metastasis of tumor by inducing tumor cells apoptosis, senescence and autophagy, which can inhibit tumor angiogenesis and enhance the sensitivity of radiotherapy and chemotherapy. Therefore, MLN4924 plays a good antitumor effect.

Key words: Neoplasms, MLN4924