Radiosensitization of artemisinin and its derivatives in tumors

doi:10.3760/cma.j.issn.1673-422X.2016.08.012

Abstract

Abstract: Artemisinin and its derivative is a kind of efficient, quick and low toxicity of antimalarial drug. In recent years, we find that artemisinin drugs can not only against malaria, but also have pharmacological effects of immunosuppression, antiviral and anticancer. A number of studies have confirmed that artemisinin and its derivatives have the radiosensitization effects in nasopharyngeal carcinoma, cervical cancer, lung cancer and glioma, and their mechanisms are related to decreasing Wee1 protein expression, increasing Cyclin B1 protein expression, blocking G2M phase and cell apoptosis.

Key words: Artemisinins, Neoplasms, Molecular mechanisms of phamacological action, Radiationsensitizing agents, Derivatives

Wang Yanjun, Jiang Yongxin, Liu Shan, Wang Hong, Ge Lyu. Radiosensitization of artemisinin and its derivatives in tumors[J]. Journal of International Oncology, 2016, 43(8): 612-614.

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