Mechanism of action of SHCBP1 in malignant tumors and progress in clinical research

doi:10.3760/cma.j.cn371439-20250331-00098

Abstract

Abstract:

SHCBP1 is a type of Src homologous collagen that can specifically bind to the SH2 structural domain. It can act as a key regulatory protein， and exhibits abnormally high expression in a variety of malignant tumors. Through affecting the processes such as cell cycle， proliferation， and invasion， it participates in tumor genesis and development. In addition， high expression of SHCBP1 is closely related to chemotherapy resistance and poor prognosis of many malignant tumors， and its targeted inhibition can enhance the sensitivity of chemotherapy and provide new therapeutic strategies for a variety of solid tumors， making it an important biomarker for prognostic assessment and a potential therapeutic target.

Key words: Neoplasms, Src homology 2 domain-containing， transforming protein 1, Cell proliferation, Cell movement, Tumor microenvironment, Prognosis

Liu Mei, Hu Yuchong, Li Fengtong, Chao Lemen, Liu Meng, Kang Linlin. Mechanism of action of SHCBP1 in malignant tumors and progress in clinical research[J]. Journal of International Oncology, 2025, 52(9): 583-586.

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