Research progress of Fusobacterium nucleatum and occurrence and development of colorectal cancer

doi:10.3760/cma.j.cn371439-20210202-00020

Abstract

Abstract:

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract, which seriously threatens human health. In recent years, many studies have found that Fusobacterium nucleatum (Fn) is positively related to the occurrence of CRC. In the process of CRC carcinogenesis, Fn can play an important role by inducing the expression of pro-inflammatory cytokines and triggering chronic inflammation, inhibiting the function of immune cells, inducing chemotherapy resistance, promoting the expressions of tumor genes and microRNAs and regulating glycolysis.

Key words: Fusobacterium nucleatum, Colorectal neoplasms, Prognosis

He Xiaokang, Tu Xian, Yao Fei, Wu Qingming. Research progress of Fusobacterium nucleatum and occurrence and development of colorectal cancer[J]. Journal of International Oncology, 2022, 49(2): 121-124.

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