Journal of International Oncology ›› 2020, Vol. 47 ›› Issue (1): 35-38.doi: 10.3760/cma.j.issn.1673-422X.2020.01.006

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Role of lncRNA MEG3 as ceRNA of miR-21 in cancer

Li Xing, Huang Junxing()   

  1. Department of Oncology, Fifth Hospital Affiliated to Nantong University (Taizhou People's Hospital of Jiangsu Province), Taizhou 225300, China
  • Received:2019-12-06 Revised:2019-12-13 Online:2020-01-08 Published:2020-03-22
  • Contact: Huang Junxing E-mail:hjxtz@sina.cn
  • Supported by:
    Medical Innovation Team Project of Jiangsu Province of China(CXTDA2017042)

Abstract:

Long non-coding RNA (lncRNA)-maternally expressed gene 3 (MEG3) and microRNA-21 (miR-21) have been widely recognized as tumor suppressor and promoter. The competing endogenous RNA (ceRNA) hypothesis provides a new strategy for studying the interaction of RNAs. In recent years, studies have shown that MEG3 can play an important role in the occurrence, development, proliferation, metastasis, drug resistance and prognosis of breast cancer, cervical cancer, gastric cancer, lung cancer, leukemia and other malignant tumors as the ceRNA of miR-21.

Key words: Neoplasms, RNA, long noncoding, Competing endogenous RNA, Maternally expressed gene 3