Journal of International Oncology

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (8): 626-628.doi: 10.3760/cma.j.issn.1673-422X.2017.08.018

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Advances of ecotropic viral integration site 1 gene in acute lymphoblastic leukemia

Lu Jiao, Liu Dandan   

  1. Department of Hematology, First Affiliated Hospital of Soochow University; Jiangsu Institute of Hematology; Key Laboratory of Thrombosis and Hemostasis, National Health and Family Planning Commission of the People′s Republic of China, Suzhou 215000, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Liu Dandan, Email: liudd_2006@126.com E-mail: liudd_2006@126.com
  • Supported by:

    National Natural Science Foundation of  China (81300424); Natural Science Foundation of Jiangsu Province of China (BK20151231)

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Abstract: As an proto-oncogene, ecotropic viral integration site 1 (EVI1) gene is overexpressed in acute myeloid leukemia (AML) because of chromosomal translocation or other genetic abnormalities, finally cause poor prognosis. In recent years, an increasing research of the expression of EVI1 in acute lymphoblastic leukemia (ALL), especially in pediatric ALL. The overexpression of EVI1 gene also suggest a poor prognosis, which is closely relate to the age. But the relationship between the expression of EVI1 gene and mixed lineage leukemia (MLL) and BCRABL gene rearrangement needs to be further studied. Researching the expression of EVI1 gene in ALL and exploring targeted therapeutic agents are important research directions in the future.

Key words: Protooncogene, Leukemia, lymphoid, Gene expression, Ecotropic viral integration site 1 gene