6-sulfo-LacNAc dendritic cells and tumors

doi:10.3760/cma.j.issn.1673-422X.2017.11.007

Abstract

Abstract: 6-sulfo-LacNAc dendritic cells (slanDCs), characterized by expressing the Fc receptors that absent in classic dendritic cells (DCs), have been identified as a novel subgroup of peripheral blood DCs. Hitherto, the majority researches of slanDCs are about inflammation and autoimmunity diseases, but a growing body of literature has shown that slanDCs may play important roles in antitumor immunity by inducing antibodydependent cellmediated cytotoxicity, releasing special cytokines, crosstalking with mesenchymal stem cells or natural killer cells, and signal transduction through Tolllike receptor pathway and mitogenactivated protein kinase pathway. slanDCs may be an ideal antitumor therapy tool.

Key words: Dendritic cells, Neoplasms, Immunity

陈邓林，陈俊民. 6-sulfo-LacNAc dendritic cells and tumors[J]. Journal of International Oncology, 2017, 44(11): 834-837.

References

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