Abstract: Objective To explore the influence of G4 cyberknife treatment of large hepatocellular carcinoma on liver function, and to evaluate its treatment safety. Methods Sixtythree large liver cancer patients treated with routine G4 cyberknife treatment were retrospectively analyzed, and then statistical analysis of the difference in liver function before and after treatment was conducted.  Results After G4 cyberknife treatment of 12 months, the levels of ALT, ALP, TBIL, PA were respectively 23.00 U/L, 111.00 U/L, 13.70 μmol/L, (81.87±13.94)%. Compared with the levels before treatment ［28.00 U/L, 32.00 U/L, 11.30 μmol/L, (86.07±14.07)%］, there were no significant differences found (Z=-1.677， P=0.094； Z=-0.504， P=0.614； Z=-1.945， P=0.053; t=1.271, P=0.213). The level of ambumin was (34.84±4.75)g/L at 12 months after treatment, which decreased and the difference compared with the level before treatment ［(37.45±4.14)g/L］ was significant (t=3.357, P=0.002). The ChildPugh grade was 5.80±1.17 respectively at the time points of 12 months after treatment, and no significant difference was found compared with the ChildPugh grade before treatment (5.48±0.81, t=-1.668, P=0.106). Conclusion G4 cyberknife treatment does not cause liver injury. It is safe and reliable in large liver cancer treatment. So, it is worth widely clinical popularizing.

Key words: Liver neoplasms, Radiotherapy, Cyberknife, Liver function